新型冠状病毒肺炎疫情期间男科实验室生物安全  

Biosafety in andrology laboratories during the outbreak of COVID-19

作　　者：杜强[1] 史轶超 邵永 武志刚[4] 许松 商学军 潘伯臣[1] DU Qiang;SHI Yi-chao;SHAO Yong;WU Zhi-gang;XU Song;SHANG Xue-jun;PAN Bo-chen(Center of Reproductive Medicine,Shengjing Hospital of China Medical University,Shenyang,Liaoning 110004,China;Center of Reproductive Medicine,Changzhou Second People's Hospital Affiliated to Nanjing Medical University,Changzhou,Jiangsu 213003,China;Department of Andrology,Jinling Hospital Affiliated to Nanjing University School of Medicine/General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China;Department of Urology and Andrology,The First Hospital Affiliated to Wenzhou Medical University,Wenzhou,Zhejiang 325000,China;Department of Urology,Jinling Hospital Affiliated to Nanjing University School of Medicine/General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China)

机构地区：[1]中国医科大学附属盛京医院生殖医学中心,辽宁沈阳110004 [2]南京医科大学附属常州第二人民医院生殖医学中心,江苏常州213003 [3]南京大学医学院附属金陵医院(东部战区总医院)男科,江苏南京210002 [4]温州医科大学附属第一医院泌尿男科,浙江温州325000 [5]南京大学医学院附属金陵医院(东部战区总医院)泌尿外科,江苏南京210002

出　　处：《中华男科学杂志》2020年第3期219-222,共4页National Journal of Andrology

基　　金：江苏省社会发展面上项目(BE2017724);江苏省“六大人才高峰”资助(WSN-069);2017年度军队计生专项研究任务计划(17JS013)。

摘　　要：2019年12月新发现的新型冠状病毒感染的肺炎(2019冠状病毒病)疫情来势迅猛,临床发现新型冠状病毒感染者和无症状感染者均可能成为传染源。尽管经呼吸道飞沫和密切接触传播被认为是主要的传播途径,但在相对封闭的环境中存在经气溶胶传播的可能。现已发现鼻咽拭子、痰和其他下呼吸道分泌物、血液、粪便、尿液等标本中可检测出新型冠状病毒核酸,精液中是否可检出新型冠状病毒核酸尚无定论。有报道发现新型冠状病毒可能影响血管紧张素转化酶2(ACE2)高表达的睾丸,同时精液与尿液的排出有着共同通道。因此,理论上精液也有可能携带病毒。男科实验室不仅可能接触包含精液在内的以上多数的体液标本,而且男科实验室的许多操作为开放性操作,有产生气溶胶的风险。因此,在新型冠状病毒疫情期间有必要采取相应的防护措施以降低感染风险。通过参照现有的疫情认知并借鉴其他相关经验,结合男科实验室的工作特点,我们将疫情期间男科实验室工作需要注意的生物安全问题进行总结,供同行参考。The novel coronavirus disease 2019(COVID-19)broke out in December 2019 and has been rapidly escalating throughout the world.Clinical findings show that the patients with either symptomatic or asymptomatic COVID-19 can be a potential source of infection.Although respiratory droplets and close contact are considered to be the main routes of transmission,there is the possibility of aerosol transmission in a relatively closed environment.The nucleic acid of the novel coronavirus can be detected in nasopharyngeal swabs,sputum and other lower respiratory tract secretions,blood,feces,urine and so on,but whether it exists in the semen has not been confirmed.It is reported that the novel coronavirus may affect the testis that highly expresses angiotensin-converting enzyme 2(ACE2)and theoretically the semen is a possible carrier of the virus considering the fact that it is discharged from the same channel as the urine.Andrology laboratorians are exposed to most of the specimens above,including semen,and some open operations in the laboratory increase the risk of aerosol generation.Therefore,corresponding protective procedures are necessitated in andrology laboratories to reduce the risk of infection during the outbreak of COVID-19.Based on the knowledge and experience available as regards the pandemic and the characteristics of the work in the andrology laboratory,we summarize some biosafety points for andrology laboratorians to attend to during the outbreak of COVID-19.

关 键 词：2019冠状病毒病 男科实验室 生物安全 

分 类 号：R183[医药卫生—流行病学]