基于证候探讨中药群体药代动力学研究的新思路  

A new approach to the study of population pharmacokinetics of Chinese medicine based on syndrome differentiation

作　　者：姜俊杰[1] 王鹤迪 刘玉庆[3] 申浩 张华 魏戌[6] 章轶立 谢雁鸣[1] JIANG Junjie;WANG Hedi;LIU Yuqing;SHEN Hao;ZHANG Hua;WEI Xu;ZHANG Yili;XIE Yanming(Institute of Basic Research in Clinic Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing 100700,China;Fengtai District Changxindian Community Health Service Center,Beijing 100072,China;Administrative Matters Acceptance Service and Complaints Reporting Center,State Drug Administration,Beijing 100053,China;Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]山东中医药大学,山东济南250355 [3]北京中医药大学东直门医院,北京100700 [4]丰台区长辛店社区卫生服务中心,北京100072 [5]国家药品监督管理局行政事项受理服务和投诉举报中心,北京100053 [6]中国中医科学院望京医院,北京100102 [7]北京中医药大学,北京100029

出　　处：《医学争鸣》2020年第3期57-59,共3页Negative

基　　金：国家自然科学基金青年基金(81603517);中华中医药学会青年人才托举工程项目(CACM-2017-QNRC2-A03)。

摘　　要：群体药代动力学是实现个体化治疗的重要方法,而中医的辨证论治更是典型的个体化治疗,与群体药代动力学理念高度一致。笔者通过试验证实:同一种中药/方剂用于不同证候患者,药物代谢存在差异。已有研究表明:药物代谢差异的重要原因是表观遗传机制。证候与表观遗传均体现环境等非先天因素对机体的影响,表观遗传机制可能是证候的内在本质。因此,推测表观遗传可能是不同证候患者药代动力学差异的机制所在。笔者提出:以表观遗传药理学为切入点,研究不同证候患者药物代谢的差异及其机制,可以成为中药群体药代动力学研究的新思路。Population pharmacokinetics is an important method to achieve individualized treatment,and syndrome differentiation and treatment of traditional Chinese medicine is a typical individualized treatment,which is highly consistent with the concept of population pharmacokinetics.The author confirmed through the experiment:the same traditional Chinese medicine/prescription used in patients with different syndromes,is different in drug metabolism.Previous studies have shown that the important reason for the difference in drug metabolism is epigenetic mechanism.Syndrome and epigenetics both reflect the influence of non-congenital factors such as environment on organism.Epigenetic mechanism may be the intrinsic nature of syndrome.Therefore,it is speculated that epigenetic inheritance may be the mechanism of pharmacokinetics differences in patients with different syndromes.The authors suggest that epigenetic pharmacology as a starting point to study the difference of drug metabolism and its mechanism in patients with different syndromes can be a new way to study the pharmacokinetics of traditional Chinese medicine.

关 键 词：中药 证候 群体药代动力学 表观遗传 

分 类 号：R285[医药卫生—中药学]