髓源性抑制细胞与移植免疫耐受研究进展  

Research progress on myeloid-derived suppressor cell and transplantation immune tolerance

作　　者：袁顺 王志维[1] Yuan Shun;Wang Zhiwei(Department of Cardiovascular Surgery,People's Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院心血管外科,430060

出　　处：《器官移植》2020年第4期435-442,共8页Organ Transplantation

基　　金：国家自然科学基金(81570428)。

摘　　要：髓源性抑制细胞(MDSC)是骨髓来源的一类异质性细胞群,最早在肿瘤中被发现,能够抑制T细胞的功能,具有免疫抑制作用。近年来越来越多的研究表明,在器官移植领域,MDSC对宿主的免疫功能也具有调节作用,能够诱导特异性免疫耐受,对移植器官发挥保护作用,有望成为临床上治疗移植排斥反应的新靶点。本文就MDSC的生物学特性和MDSC诱导免疫耐受的机制进行综述。Myeloid-derived suppressor cell(MDSC)is a type of heterogeneous cell derived from bone marrow,which was first found in tumor.MDSC can inhibit the function of T cell with immunosuppressive effect.In recent years,more and more studies have shown that in the field of organ transplantation,MDSC can also regulate the host's immune function,induce specific immune tolerance,and play a protective role in transplant organs,which is expected to become a new target in clinical treatment of transplant rejection.The biological characteristics of MDSC and the mechanism of immune tolerance induced by MDSC were reviewed in this paper.

关 键 词：髓源性抑制细胞 免疫耐受 器官移植 排斥反应 移植免疫 调节性T细胞(Treg) 诱导型一氧化氮合酶 程序性细胞死亡受体-1(PD-1) 

分 类 号：R617[医药卫生—外科学] R329.4[医药卫生—临床医学]