肝移植术后人类疱疹病毒6型感染的研究进展  

Research progress on human herpesvirus 6 infection after liver transplantation

作　　者：刘敏 孙丽莹[1] Liu Min;Sun Liying(Beijing Friendship Hospital,Capital Medical University,Clinical Diagnosis and Research Center of Pediatric Liver Transplantation of Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院首都医科大学儿童肝脏移植临床诊疗与研究中心,100050

出　　处：《器官移植》2020年第4期502-507,515,共7页Organ Transplantation

基　　金：北京市医院管理局“登峰”人才培养计划(DFL20150101)。

摘　　要：人类疱疹病毒6型(HHV-6)初始侵入宿主体内后可终身潜伏,而肝移植受者在免疫抑制期间可出现潜伏感染的再激活。肝移植受者HHV-6感染可导致发热、肝炎、脑炎以及移植物功能障碍,并间接增加了巨细胞病毒(CMV)、丙型肝炎病毒(HCV)感染所致肝纤维化进展的风险。目前,肝移植术后HHV-6感染的发病机制尚未系统阐明,并缺乏有效的防治策略。本文就肝移植术后HHV-6感染的发病机制、危险因素、诊断和治疗方法等方面的进展进行综述。Human herpesvirus 6(HHV-6)may establish lifetime latency after initial invasion of the host,and liver transplant recipients may experience reactivation of latent infection during immunosuppression.HHV-6 infection in liver transplant recipients could lead to fever,hepatitis,encephalitis and graft dysfunction,and indirectly increases the risk of progression of liver fibrosis due to cytomegalovirus(CMV),hepatitis C virus(HCV)infection.At present,the pathogenesis of HHV-6 infection after liver transplantation has not been systematically elucidated,and effective prevention and treatment strategies are still lacking.This article provided a review for the research progress on the pathogenesis,risk factors,diagnosis and treatment of HHV-6 infection after liver transplantation.

关 键 词：肝移植 人类疱疹病毒6型 巨细胞病毒 丙型肝炎病毒 潜伏感染 免疫抑制 淋巴细胞 机会性感染 

分 类 号：R617[医药卫生—外科学] R752.1[医药卫生—临床医学]