持续低温机械灌注保存移植肾的作用及其研究进展  

Effect and research progress on continuous hypothermic machine perfusion in preservation of renal graft

作　　者：张飞[1] 廖贵益[1] Zhang Fei;Liao Guiyi(Department of Urology,the First Affiliated Hospital of Anhui Medical University,Hefei 230000,China)

机构地区：[1]安徽医科大学第一附属医院泌尿外科,合肥230000

出　　处：《器官移植》2020年第4期521-525,共5页Organ Transplantation

基　　金：安徽省自然科学基金(1508085SMH226)。

摘　　要：公民逝世后器官捐献中不可避免的缺血-再灌注损伤(IRI)往往导致移植物功能延迟恢复(DGF)。利用LifePort对移植肾进行持续低温机械灌注(HMP)在一定程度上降低了DGF的发生率,但移植肾DGF仍然是临床面临的严重问题。肾移植科医师应在充分认识移植肾持续HMP作用的基础上,不断进行更深入的基础与应用研究,以期进一步降低移植肾DGF的发生率。本文主要就持续HMP保存移植肾的作用及其研究进展作一综述。Inevitable ischemia-reperfusion injury(IRI)occurred in organ donation after citizen's death often results in delayed graft function(DGF)after renal transplantation.Although the incidence of DGF had reduced to some extent due to continuous hypothermic machine perfusion(HMP)for renal graft using LifePort,DGF of renal graft remains a major clinical problem.In order to further reduce the incidence of DGF after renal transplantation,renal transplant surgeons should fully understand the role of continuous HMP in renal transplantation,continue to conduct more in-depth basic and applied research.This article mainly summarized the effect of continuous HMP on renal transplantation and its research progress.

关 键 词：肾移植 低温机械灌注 移植物功能延迟恢复 缺血-再灌注损伤 扩大标准供者 LifePort 机械灌注流量 阻力指数 

分 类 号：R617[医药卫生—外科学]