消栓肠溶胶囊改善慢性脑缺血患者脑循环及认知功能的临床研究  

Clinical Study on the Improvement of Blood Flow and Cognitive Function in Chronic Cerebral Hypoperfusion Patients with Xiaoshuan Enteric Capsule

作　　者：王旭生[1] 刘伟[2] 张萍[1] 曾皎 穆俊林[1] 宋景贵[1] WANG Xusheng;LIU Wei;ZHANG Ping;ZENG Jiao;MU Junlin;SONG Jinggui(The Second Affiliated Hospital of Henan Xinxiang Medical College,Xinxiang 453002;Henan Xinxiang Central Hospital,Xinxiang 453002)

机构地区：[1]河南省新乡医学院第二附属医院,河南新乡453002 [2]河南省新乡市中心医院,河南新乡453002

出　　处：《湖北中医药大学学报》2020年第2期37-40,共4页Journal of Hubei University of Chinese Medicine

基　　金：河南省高等学校重点科研项目计划(项目编号:18A320033);河南省医学科技攻关计划项目(项目编号:201702130)。

摘　　要：目的观察消栓肠溶胶囊对慢性脑缺血患者脑部血流及认知功能的改善作用。方法选取我院收治的120例慢性脑缺血患者,随机分为对照组(60例)采取常规药物治疗,实验组(60例)在对照组治疗基础上联合消栓肠溶胶囊口服治疗,监测患者脑部血流动力学、血液流变学及脑灌注的情况,并采用蒙特利尔认知评估量表(MoCA)评价患者认知功能的改善情况,同时记录患者不良反应发生情况。结果治疗后,实验组患者的前分水岭区白质、中动脉区白质、后动脉区白质的平均脑血流量(r-CBF)水平明显高于对照组(均P<0.05);实验组患者的大脑双侧前动脉(ACA)、双侧中动脉(MCA)、双侧后动脉(PCA)、双侧基地动脉(BA)的平均血流速度(Vm)均值明显高于对照组(均P<0.05);实验组患者的高切全血粘度(HS)、低切全血粘度(LS)、血浆粘度(PV)、纤维还原蛋白(PV)以及红细胞压积(HCT)明显低于对照组(均P<0.05);实验组治疗后的命名、注意力、语言、定向力、延迟回忆、抽象、视空间功能的评分及MoCA量表总分明显高于对照组(均P<0.05);两组患者的不良反应发生率比较无统计学意义(P>0.05)。结论消栓肠溶胶囊可有效促进脑循环,提高脑血流灌注,改善认知功能,具有一定的临床推广应用价值。Objective To observe the effect of Xiaoshuan enteric capsule on improving blood flow and cognitive function in chronic cerebral hypoperfusion patients. Methods 120 cases of patients with chronic cerebral hypoperfusion were randomly divided into observation group and control group,60 cases each. Control group was treated with conventional drug,treatment group was treated with Xiaoshuan enteric capsule on the basis of control group to monitor the brain hemodynamics,hemorheology and cerebral perfusion. Results After treatment,the mean cerebral blood flow(r-CBF)in white,middle arterial and posterior arterial regions of observation group were significantly higher than those in control group(all P<0.05);the mean blood flow velocity(Vm)of anterior cerebral artery(ACA),bilateral middle artery(MCA),bilateral posterior artery(PCA)and bilateral base artery(BA)in observation group were significantly higher than those in control group(all P<0.05);the mean blood viscosity(LS),plasma(PV),fibrinogen(PV)and hematocrit(HCT)were significantly lower than those in control group(all P<0.05);the scores of naming,attention,language,orientation,delayed recall,abstract and visual function and the total score of MoCA scale of observation group were significantly higher than those of control group(all P<0.05). Conclusion Xiaoshuan enteric capsule can effectively promote cerebral circulation,improve cerebral blood flow perfusion and improve cognitive function,and has certain clinical application value.

关 键 词：慢性脑缺血 消栓肠溶胶囊 脑循环 认知功能 

分 类 号：R259[医药卫生—中西医结合]