二苯甲酮衍生物对酪氨酸酶生物活性的影响  

Effect of Benzophenone Derivatives on Tyrosinase Activity

作　　者：刘清 曾福燃 蒋汇锋 冯安生[1] 邹训重 游遨[1] LIU Qing;ZENG Furan;JIANG Huifeng;FENG Ansheng;ZOU Xunzhong;YOU Ao(Department of Environmental Engineering,Guangdong Industry Polytechnic,Guangzhou 510300,China)

机构地区：[1]广东轻工职业技术学院生态环境技术学院,广州510300

出　　处：《药学与临床研究》2020年第3期186-188,共3页Pharmaceutical and Clinical Research

基　　金：广东省教育厅项目(2017GKCXTD001,2017GkQNCX004);广东省大学生科技创新培育专项资金项目(pdjh2019b0689);广东轻工职业技术学院大学生创新项目(1083319010)。

摘　　要：报道了11种二苯甲酮衍生物对酪氨酸酶生物活性的影响。结果显示,7种化合物对酪氨酸酶表现出激活效应,其中4-羟基二苯甲酮与-3羟基二苯甲酮对酪氨酸酶最大激活率分别达到230%和214%。当化合物中羟基被其他官能团,如甲基、甲氧基、氟等取代之后,这类化合物对酪氨酸酶的激活效应会大幅度降低,甚至消失。动力学研究显示,4-羟基二苯甲酮与3-羟基二苯甲酮对酪氨酸酶激活动力学模式均为非竞争性。The biological effects of 11 benzophenone derivatives on tyrosinase were reported.The results showed that 7 compounds showed activated tyrosinase,among which the maximum activation rates of 4-hydroxydiphenylketone and 3-hydroxydiphenylketone reached 230%and 214%,respectively.When the hydroxyl group in the compound was replaced by other functional groups such as methoxy group,methyl group or fluorine,the activation effects of these compounds on tyrosinase reduced greatly or even disappeared,and the kinetic modes of tyrosinase activation by 4-hydroxydiphenylketone and 3-hydroxydiphenylketone were non-competitive.

关 键 词：二苯甲酮衍生物 酪氨酸酶 激活 

分 类 号：R969.2[医药卫生—药理学]