多指标综合加权评分法优选消瘿散结合剂的提取工艺  

Optimizing Extraction Process of Xiaoyingsanjie Decoction by Comprehensive Evaluation of Multiple Marks

作　　者：马晓琨 朱建勇[1] 宋雅楠[1] 张春燕[1] 叶颖[1] 夏伟[1] MA Xiaokun;ZHU Jianyong;SONG Yanan;ZHANG Chunyan;YE Ying;XIA Wei(Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)

机构地区：[1]上海中医药大学附属第七人民医院,上海200137

出　　处：《药学与临床研究》2020年第3期189-192,共4页Pharmaceutical and Clinical Research

基　　金：上海市浦东新区“国家中医药发展综合改革试验区”建设项目(PDZY-2019-0807);上海市浦东新区卫生健康委员会卫生科技项目(PW2019A-1)。

摘　　要：目的:优选消瘿散结合剂的提取工艺。方法:采用L9(34)正交设计,以丹酚酸B、橙皮苷、迷迭香酸的含量及出膏率的综合评分为指标,考察料液比、提取时间、提取次数对提取效果的影响,优选消瘿散结合剂的最佳提取工艺。结果:根据综合评分的结果,优选出最佳提取工艺为加10倍水,提取2次,每次1 h。结论:该工艺准确可靠,提取率高,可行性好。Objective:To investigate the extraction process of Xiaoyingsanjie Decoction.Methods:Orthogonal tests were used to investigate the effects of crude drug-water ratio,length and frequency on extraction efficiency.The extraction process was optimized by comprehensive evaluation indexes including the contents of salvianolic acid B,hesperidin and rosmarinic acid,and the yields of extracts.Result:According to the results of comprehensive scoring,the optimal extraction conditions of this preparation were as follows:Crude drugs were best extracted twice with 10 times of water for 1 h.Conclusion:This optimized process is simple,feasible,repeatable and suitable for the industrial production of Xiaoyingsanjie Decoction.

关 键 词：消瘿散结合剂 正交实验 丹酚酸B 橙皮苷 迷迭香酸 综合加权 

分 类 号：R943[医药卫生—药剂学] TQ460.6[医药卫生—药学]