糖尿病专用型肠内营养混悬液对重症脑卒中合并应激性高血糖患者的影响  

Effects of TPF-DM on Patients with Severe Stroke Complicated with Stress Hyperglycemia

作　　者：万莉[1] 冯锐[1] 芦雪峥 王佩[1] 李红闪[1] 魏书艳[1] WAN Li;FENG Rui;LU Xuezheng;WANG Pei;LI Hongshan;WEI Shuyan(Three departments of Neurology,Baoding First Central Hospital,Baoding 071000,China)

机构地区：[1]保定市第一中心医院神经内三科,保定071000

出　　处：《药学与临床研究》2020年第3期218-221,共4页Pharmaceutical and Clinical Research

基　　金：定市科技计划项目(17ZF276)。

摘　　要：目的:探讨糖尿病专用型肠内营养混悬液(TPF-DM)对重症脑卒中合并应激性高血糖患者血糖及降钙素原(PCT)水平的影响。方法:将48例并发应激性高血糖的重症脑卒中患者随机均分两组,经整理后每组各20例,分别给予肠内营养混悬液TPF(对照组)和TPF-DM(研究组)作为肠内营养支持。于入院第1、7、14天分别抽取患者静脉血测定空腹血糖(FBG)、餐后2小时血糖(2hPBG)及PCT水平,对组间指标进行统计学分析。结果:研究组第7天和第14天血糖水平均低于同期对照组(P<0.05);两组患者在第1天监测PCT水平均高于正常,营养支持后第7天研究组与对照组PCT水平均较第一天下降,但相比之下研究组PCT改善较对照组显著,差异有统计学意义(P<0.05);第14天两组患者PCT水平均恢复至正常水平且组间差异不再有统计学意义(P>0.05)。结论:TPF-DM对重症脑卒中合并应激性高血糖患者血糖影响显著优于TPF,可能对早期感染的控制产生积极影响。Objective:To inves tigate the effects of diabetic enteral nutrition suspension(TPF-DM)on blood glucose and procalcitonin(PCT)levels in patients with severe stroke complicated with stress hyperglycemia.Methods:Forty-eight patients with severe stroke complicated with stress hyperglycemia were randomly divided into experimental group and control group with 24 cases in each group.The two groups of patients were treated with TPF and TPF-DM as the enteral nutrition support,respectively.Venous blood indexes:fasting blood glucose(FBG),2h postprandial blood glucose(2hPBG)and PCT were measured on day 1,7 and 14 after enteral nutrition.The inter-group indicators were statistically analyzed.Results:Blood glucose levels in the TPF-DM group on day 7 and day 14 were obviously lower than the TPF control group(P<0.05).At day1,the PCT was higher than normal,but with no significant difference between the two groups(P>0.05).At day7,PCT decreased compared to day 1 in both the TPF-DM and TPF groups,but the improvement of PCT in the TPF-DM group was significantly higher than that in the control group(P<0.05).At day14,PCT levels returned to normal in both groups and there was no significant difference between the two groups(P>0.05).Conclusion:TPF-DM has a significantly better effect than TPF on blood glucose in patients with severe stroke complicated with stress hyperglycemia,and may have a positive effect on the control of early infection.

关 键 词：肠内营养 重症脑卒中 应激性高血糖 降钙素原 

分 类 号：R969.4[医药卫生—药理学]