儿童过敏性疾病实验室检查的现状与进展  

The status and progress of laboratory tests for pediatric allergic disease

作　　者：叶青[1] 尚世强[1] Ye Qing;Shang Shiqiang(Laboratory Center,Children′s Hospital,Zhejiang University School of Medicine,National Clinical Research Center For Child Health,Hangzhou 310052,China)

机构地区：[1]浙江大学医学院附属儿童医院实验检验中心国家儿童健康与疾病临床医学研究中心,杭州310052

出　　处：《中华检验医学杂志》2020年第5期515-518,519,共5页Chinese Journal of Laboratory Medicine

摘　　要：过敏性疾病严重威胁儿童健康和生命,给社会带来了沉重的经济负担,被世界卫生组织列为了21世纪重点研究和防治的三大疾病之一。儿童过敏性疾病的临床诊断主要基于病史、体格检查、过敏原特异性体内试验以及体外试验。一些新方法和潜在标志物有望提升儿童过敏性疾病诊断的准确性和可靠性。过敏原分子组分研究及基于多组学的新的过敏相关标志物的筛选将成为未来儿童过敏性疾病实验室检查的发展方向。Allergic diseases posed a serious threat to children′s healthy quality and life safty,and brought heavy economic burden to the society.The clinical diagnosis of allergic diseases is mainly based on the history of disease,the physical examination,the in vivo test and the in vitro test.In addition,some new methods and potential markers have been indicated as the promising strategies for the in vitro tests for the diagnosis of allergic diseases.The study of allergen molecular composition and the screening of new allergen-related markers based on multi-omics are the future development directions of laboratory testing of allergic diseases in pediatrics.

关 键 词：超敏反应 变应原 临床实验室技术 皮肤试验 生物标记 儿童 

分 类 号：R725.9[医药卫生—儿科] R446[医药卫生—临床医学]