TORCH实验室规范化检测与临床应用专家共识  

Expert consensus on standardized TORCH laboratory detection and clinical application

作　　者：朱宇宁[1] 尚世强[2] 陈英虎[2] 陈大鹏[3] 贾莉婷[4] 渠巍 柯江维[6] 李海波[7] 李晓勤 梁秀云[9] 刘艳秋[10] 马丽娟[11] 莫丽亚[12] 阮强[13] 沈国松 王雨新 许红[16] 徐锦 徐两蒲[18] 许晓红 袁恩武[4] 张乐海[20] 张文利 张欣文[22] Zhu Yuning;Shang Shiqiang;Chen Yinghu;Chen Dapeng;Jia Liting;Qu Wei;Ke Jiangwei;Li Haibo;Li Xiaoqin;Liang Xiuyun;Liu Yanqiu;Ma Lijuan;Mo Liya;Ruan Qiang;Shen Guosong;Wang Yuxin;Xu Hong;Xu Jin;Xu Liangpu;Xu Xiaohong;Yuan Enwu;Zhang Lehai;Zhang Wenli;Zhang Xinwen(Department of Clinical Laboratory,Branch of National Clinical Research Center for Obstetrics&Gynecology,Women′s Hospital,Zhejiang University,Hangzhou 310006,China;Laboratory Center,National Clinical Research Center for Child Health,National Children′s Regional Medical Center,Children′s Hospital,Zhejiang University,Hangzhou 310052,China;Department of Clinical Laboratory,Children′s Hospital of Chongqing Medical University,Chongqing 400014,China;Department of Clinical Laboratory,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Clinical Laboratory,Guiyang Maternal and Child Health Hospital,Guiyang 550003,China;Department of Clinical Laboratory,the Children′s Hospital of Jiangxi Province,Nanchang 330006,China;Department of Clinical Laboratory,Nantong Maternal and Child Health Hospital,Nantong 226018,China;Department of Clinical Laboratory,the Xinjiang Uygur Autonomous Region Maternal and Child Health Care Hospital,Urumqi 830000,China;Department of Clinical Laboratory,the Second Nanning People′s Hospital,Nanning 530031,China;Prenatal Diagnosis Center,Jiangxi Provincial Maternal and Child Health Hospital,Nanchang 330006,China;Department of Clinical Laboratory,Capital Institute of Pediatrics Affiliated Children′s Hospital,Beijing 100020,China;Department of Clinical Laboratory Center,Hunan Provincial Children′s Hospital,Changsha 410007,China;Virus Laboratory,Shengjing Hospital,China Medical University,Shenyang 110004,China;Department of Clinical Laboratory,Huzhou Maternity&Child Health Care Hospital,Huzhou 313000,China;Department of Clinical Laboratory,Dalian Maternal and Child Health Hospital,Dalian 116033,China;Department of Clinical Laboratory,Shijiazhuang Fourth Hospital,Shijiazhuang 050011,China;Departm

机构地区：[1]浙江大学医学院附属妇产科医院检验科,国家妇产区域医疗中心,杭州310006 [2]浙江大学医学院附属儿童医院实验检验中心,国家儿童健康与疾病临床医学研究中心,杭州310052 [3]重庆医科大学附属儿童医院检验科,重庆400014 [4]郑州大学第三附属医院检验科,郑州450052 [5]贵阳市妇幼保健院/贵阳市儿童医院检验科,贵阳550003 [6]江西省儿童医院检验科,南昌330006 [7]南通市妇幼保健院检验科,南通226018 [8]新疆维吾尔自治区妇幼保健院检验科,乌鲁木齐830000 [9]南宁市第二人民医院检验科,南宁530031 [10]江西省妇幼保健院产前诊断中心,南昌330006 [11]首都儿科研究所附属儿童医院检验中心,北京100020 [12]湖南省儿童医院检验中心,长沙410007 [13]中国医科大学附属盛京医院病毒研究室,沈阳110004 [14]湖州市妇幼保健院检验科,湖州313000 [15]大连市妇幼保健院检验科,大连116033 [16]石家庄市第四医院检验科,石家庄050011 [17]复旦大学附属儿科医院临床检验中心,上海201102 [18]福建省妇幼保健院检验科,福州350001 [19]安徽省妇幼保健院检验科,合肥230001 [20]济南市儿童医院科教外事科,济南250000 [21]乌鲁木齐儿童医院检验科,乌鲁木齐830002 [22]西安市妇产医院/西安市第四医院妇产科,西安710004

出　　处：《中华检验医学杂志》2020年第5期553-561,共9页Chinese Journal of Laboratory Medicine

摘　　要：TORCH指一组病原体,包含弓形虫、风疹病毒、巨细胞病毒、单纯疱疹病毒等,孕妇感染此类病原体后可通过胎盘或产道感染胎儿或者新生儿,可能导致流产、早产、畸胎、死胎、宫内发育迟缓、新生儿多器官损害等不良预后。对于多数孕期TORCH感染,目前尚缺乏有效的治疗手段,加强孕前、产前TORCH感染监测至关重要。TORCH实验室检测在其中发挥着重要作用,但TORCH检测流程的规范化、检验结果的正确解读尚需形成共识性意见。本文基于TORCH检测方法特点,针对不同病原体的感染特点、感染类型,从实验室角度对TORCH规范化检测与临床应用给出了共识性意见。TORCH,which is considered as a series of pathogens,including the Toxoplasma gondii,Rubella virus,Cytomegalovirus or Herpes simplex virus,often infects the pregnant women to induce the the fetus or newborn infection by transplacental infection or exposure to contaminated genital tract secretions at delivery.Increasing evidence have been confirmed that the infection of TORCH may cause the miscarriage,premature birth,malformed fetus,stillbirth,intrauterine growth retardation,neonatal multiple organ dysfunction and other adverse pregnancy outcomes.For most TORCH-infections cases may lacking the effective treatments during pregnancy,and it is important to achieve the effacing monitoring of TORCH infections before and during pregnancy.The laboratory testing of TORCH has the great significance.However,the consensus opinions still need to improve the the standardization of TORCH testing process and the correct interpretation.Based on the characteristics of the TORCH detection method,this article gives a consensus opinion on the standardized detection and clinical application of TORCH from the laboratory perspective according to the characteristics and types of infection of different pathogens.

关 键 词：巨细胞病毒感染 单纯疱疹 风疹 弓形虫病 临床实验室技术 参考标准 

分 类 号：R446[医药卫生—诊断学]