聚乙二醇化壳聚糖的制备及其应用研究进展  

Progress in Preparation and Application of PEGylated Chitosans

作　　者：王婷[1,2] 蔡照胜 徐清 Wang Ting;Cai Zhaosheng;Xu Qing(School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou,225002;School of Chemistry and Chemical Engineering,Yancheng Institute of Technology,Yancheng,224051)

机构地区：[1]扬州大学化学化工学院,扬州225002 [2]盐城工学院化学化工学院,盐城224051

出　　处：《化学通报》2020年第6期536-545,共10页Chemistry

基　　金：江苏省生物质能源与材料重点实验室开放基金项目(JSBEM201607);江苏省研究生科研与实践创新计划项目(SJCX18_0888);国家自然科学基金项目(21672163);浙江省杰出青年学者自然科学基金项目(LR14B020002)资助。

摘　　要：聚乙二醇(PEG)是一种具有无毒、亲油亲水、高生物相容和无免疫原性等特点的化合物。将聚乙二醇结构引入壳聚糖(CTS)糖链中得到的聚乙二醇化壳聚糖,不但保持了CTS的天然性和优良生物降解等特性,还具有更好的水溶性和对有机化合物的结合能力。通过对CTS进行聚乙二醇化改性,可进一拓展其应用领域。本文结合近20年国内外PEG改性CTS的研究特点,围绕PEG改性CTS的制备及其在药物负载与控制释放、组织工程、抗菌材料、生物活性物传递和环境保护等领域的应用进行了总结,并展望其未来的发展趋势。Polyethylene glycol(PEG)is a non-toxic,lipophilic and hydrophilic compound which characterized with high biocompatibility and non-immunogenicity.Chitosan(CTS)can be transformed into PEGylated chitosan by introducing PEG into its sugar chain.It not only maintains the natural and excellent biodegradability of chitosan,but also has better water solubility and ability to bind organic compounds.The fields concerned with the application of CTS can be expanded through PEGylated modification.On basis of the relevant research traits in the past 20 years,the preparation of PEGylated chitosans and their application in the domains of drug loading and controlled release,tissue engineering,antibacterial materials,bioactive material delivery and environmental protection are summarized,and the future development trend is prospected.

关 键 词：壳聚糖 聚乙二醇 改性 应用 

分 类 号：O636.1[理学—高分子化学]