甲氨蝶呤与来氟米特治疗类风湿性关节炎的临床疗效和安全性分析  

Clinical efficacy and safety analysis of methotrexate and leflunomide in the treatment of rheumatoid arthritis

作　　者：赵玉贵 ZHAO Yu-gui(Center for Disease Control and Prevention,Honggang District,Daqing City,Heilongjiang Province,Heilongjiang Daqing 163000,China)

机构地区：[1]黑龙江省大庆市红岗区疾病预防控制中心,黑龙江大庆163000

出　　处：《临床医药文献电子杂志》2020年第40期7-8,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的分析甲氨蝶呤与来氟米特治疗类风湿性关节炎的临床疗效和安全性。方法选取类风湿性关节炎患者(110例),将其分为实验组和对照组,对照组(55例),采取甲氨蝶呤治疗,实验组(55例),采取甲氨蝶呤联合来氟米特治疗,对比两组患者临床疗效以及不良反应发生情况。结果实验组的总有效率明显高于对照组,P<0.05;不良反应发生率低于对照组,P>0.05。结论甲氨蝶呤与来氟米特治疗类风湿性关节炎的临床疗效确切。Objective To analyze the clinical efficacy and safety of methotrexate and leflunomide in the treatment of rheumatoid arthritis.Methods Patients with rheumatoid arthritis(110 cases)were selected and divided into experimental group and control group.The control group(55 cases)was treated with methotrexate.The experimental group(55 cases)was treated with methotrexate In the treatment of leflunomide,the clinical efficacy and adverse reactions of the two groups of patients were compared.Results The total effective rate of the experimental group was significantly higher than that of the control group,P<0.05;the incidence of adverse reactions was lower than that of the control group,P>0.05.Conclusion The clinical efficacy of methotrexate and leflunomide in treating rheumatoid arthritis is definite.

关 键 词：甲氨蝶呤 来氟米特 类风湿性关节炎 

分 类 号：R593.22[医药卫生—内科学]