南充地区33153名体检者幽门螺杆菌感染情况及其与动脉硬化危险因素的相关性分析  

Helicobacter pylori infection and the correlation with risk factors of atherosclerosis of 33 153 physical examinees in Nanchong

作　　者：李芸[1] 刘菊华 田维科 雷蓉[1] 柳弥[1] LI Yun;LIU Juhua;TIAN Weike;LEI Rong;LIU Mi(Health Management Center,Affiliated Hospital of North Sichuan Medical College,Sichuan Province,Nanchong 637000,China;Department of Clinical Medicine of Integrated Chinese and Western Medicine,Chengdu University of Traditional Chinese Medicine,Sichuan Province,Chengdu 610032,China)

机构地区：[1]川北医学院附属医院健康管理中心,四川南充637000 [2]成都中医药大学中西医结合临床医学院,四川成都610032

出　　处：《中国医药导报》2020年第17期53-56,共4页China Medical Herald

基　　金：四川省南充市市校科技战略合作专项项目(18SXHZ0301)。

摘　　要：目的分析四川省南充地区体检人群幽门螺杆菌(Hp)感染情况及其与动脉硬化危险因素的相关性。方法选择2015年11月~2019年7月在川北医学院附属医院健康管理中心进行健康体检者33 153名作为研究对象,根据Hp感染情况将受检者分为Hp阳性组(13 948例)和Hp阴性组(19 205名)。分析Hp感染与血脂、C反应蛋白、空腹血糖、糖化血红蛋白、尿酸(UA)、同型半胱氨酸(Hcy)的关系。结果不同年龄人群Hp感染率比较,差异无统计学意义(P> 0.05)。Hp阳性组三酰甘油(TG)、极低密度脂蛋白胆固醇(VLDL-C)、UA及年龄均高于Hp阴性组,高密度脂蛋白胆固醇(HDL-C)低于阴性组,差异有高度统计学意义(P <0.01)。单因素logistic分析显示,HDL-C、性别是Hp感染的保护因素(OR <1,P <0.01),TG、VLDL-C、UA、年龄是Hp感染的危险因素(OR> 1,P <0.01)。多因素回归分析显示,HDL-C为Hp感染的保护因素(P <0.01)。结论 Hp感染与脂代谢紊乱相关,HDL-C值越高,Hp感染可能性越小,为保护因素。Objective To analyze the prevalence of Helicobacter pylori(Hp)infection and the correlation with risk factors of atherosclerosis in physical examination population in Nanchong.Methods A total of 33153 health examiners who underwent health examination from November 2015 to July 2019 in Health Management Center of Affiliated Hospital of North Sichuan Medical College were selected as the research subjects.According to the Hp infection,the examinees were divided into Hp positive group(13948 cases)and Hp negative group(19205 cases).The relationship between Hp infection and blood lipids,C-reactive protein,fasting plasma glucose,glycated hemoglobin,uric acid(UA),homocysteine(Hcy)were analyzed.Results There was no statistically significant difference in Hp infection rate among different age groups(P>0.05).Triacylglycerol(TG),very low density lipoprotein cholesterol(VLDL-C),UA and age of Hp positive group were higher than those of Hp negative group,high density lipoprotein cholesterol(HDL-C)was lower than that of Hp negative group,and the differences were highly statistically significant(P<0.01).Univariate logistic analysis showed that HDL-C and gender were protective factors for Hp infection(OR<1,P<0.01),while TG,VLDL-C,UA and age were risk factors for Hp infection(OR>1,P<0.01).Multivariate regression analysis showed that HDL-C was a protective factor for Hp infection(P<0.01).Conclusion Hp infection is associated with dyslipidemia.The higher the HDL-C value,the lower the possibility of Hp infection,which is a protective factor.

关 键 词：幽门螺旋杆菌 动脉硬化 血脂 危险因素 

分 类 号：R543.5[医药卫生—心血管疾病]