孕前女性甲状腺功能筛查新模式的研究  

Study on the new model of thyroid function screening before pregnancy

作　　者：丁旭锋 胡玉清 马年娣 马韦 范俊[3] DING Xufeng;HU Yuqing;MA Niandi;MA Wei;FAN Jun(Department of Reproductive Health,Maternal and Child Health Care Hospital of Yixing,Jiangsu Province,Wuxi 214200,China;Department of Medical Laboratory,Maternal and Child Health Care Hospital of Yixing,Jiangsu Province,Wuxi 214200,China;Jiangsu Institute of Nuclear Medicine,Jiangsu Province,Wuxi 214063,China)

机构地区：[1]江苏省宜兴市妇幼保健院生殖健康科,江苏无锡214200 [2]江苏省宜兴市妇幼保健院检验科,江苏无锡214200 [3]江苏省原子医学研究所,江苏无锡214063

出　　处：《中国医药导报》2020年第17期105-108,共4页China Medical Herald

基　　金：江苏省妇幼健康科研项目(F201759)。

摘　　要：目的探讨孕前女性甲状腺功能筛查新模式的可行性。方法选择2019年1~4月在江苏省宜兴市妇幼保健院婚检中心进行免费孕前优生检查的女性1026例,其中促甲状腺素(TSH)在0.1~2.5 mU/L区间共719例,采用时间分辨荧光免疫分析法(TRFIA)检测甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)。采用罗氏电化学发光法验证TRFIA检测结果,观察TRFIA检测与罗氏电化学发光法的符合率。结果 719例患者中,TRFIA多筛查出TPOAb阳性36例,占比5.01%;TgAb阳性31例,占比4.31%。36例TPOAb阳性患者中,18例经课题经费验证,12例经门诊自费复诊验证,6例拒绝复查;31例TgAb阳性患者中,15例经课题经费验证,13例经门诊自费复诊验证,3例拒绝复查。课题经费及门诊复诊验证结果均显示,TRFIA检测甲状腺抗体阳性率与罗氏电化学发光法符合率较高,TPOAb阳性符合率分别为94.44%及91.67%,TgAb阳性符合率分别为93.33%及84.62%。结论 TRFIA的准确率较高,该技术运用于孕前女性甲状腺功能筛查的新模式有利于早期发现TPOAb、TgAb,促进优生优育。Objective To explore the potentiality of a new thyroid function screening before pregnancy.Methods A total of 1026 females came from Maternal and Child Health Care Hospital of Yixing and prepared for pregnancy were enrolled.The concentrations of serum TPOAb and TgAb were detected by TRFIA in 719 cases whose TSH between0.1-2.5 m U/L.Results of TRFIA were confirmed by Roche electrochemical luminescence,and the coincidence rate between TRFIA test and Roche electrochemical luminescence was observed.Results Among the 719 patients,TRFIA detected more TPOAb positive in 36 cases,accounting for 5.01%.TgAb positive in 31 cases,accounting for 4.31%.Of the 36 patients with positive TPOAb,18 patients were confirmed by the project funds,12 patients were confirmed by outpatient self-funded,and 6 patients refused to be reviewed.Among the 31 patients with positive TgAb,15 patients were confirmed by the project funds,13 patients were confirmed by outpatient self-funded,and 3 patients refused to be reviewed.Both of the project funds and the outpatient self-funded verification results showed that,the positive rate of thyroid antibody detected by TRFIA was highly consisted with that of Roche electrochemical luminescence method,the compliance rates of TRFIA and ECLIA on TPOAb were 94.44%and 91.67%,respectively,and those of TgAb were93.33%and 84.62%,respectively.Conclusion The accuracy of TRFIA is relatively high.The new mode is conducive to the early discovery of TPOAb and TgAb in thyroid function screening of women before pregnancy,and it helps to promote bear and rear better children.

关 键 词：甲状腺抗体 孕前甲状腺功能筛查模式 时间分辨荧光免疫分析法 

分 类 号：R714.1[医药卫生—妇产科学]