参赭培气汤加减治疗食管低级别上皮内瘤变的临床效果  

Clinical effect of modified Shenzhe Peiqi Decoction in treatment of esophageal low-grade intraepithelial neoplasia

作　　者：阳思诗[1] 江潮 邵迎新 YANG Sishi;JIANG Chao;SHAO Yingxin(Department of Spleen and Stomach Diseases,Huanggang Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine,Hubei Province,Huanggang 438000,China)

机构地区：[1]湖北中医药大学附属黄冈市中医医院脾胃病科,湖北黄冈438000

出　　处：《中国医药导报》2020年第17期165-168,共4页China Medical Herald

基　　金：湖北省黄冈市科技计划项目(黄科字[2017]5号);湖北省中医药科研立项项目(ZY2019M003)。

摘　　要：目的观察参赭培气汤加减治疗食管低级别上皮内瘤变的临床效果。方法选取2017年1月~2018年1月就诊于湖北中医药大学附属黄冈市中医医院脾胃病科门诊及住院的食管低级别上皮内瘤变患者共50例,采用随机数字表法将其分为对照组和治疗组,各25例。对照组给予西药抑酸护胃,治疗组口服参赭培气汤加减方,疗程8周。治疗前及疗程开始后1、2、4、8周分别作中医证候评分量表的总积分判定中医证候疗效,疗程结束后停药4周,再次行电子胃镜检查,分别对内镜下表现、病理组织学表现情况加以统计,计算各病理表现及总分的改善程度。疗程结束后停药,并对所有病例跟踪随访24周以了解有无病情变化。结果治疗组的中医证候疗效、内镜下食管黏膜疗效及病理组织学疗效均优于对照组,差异有统计学意义(P <0.05)。结论参赭培气汤加减方治疗食管低级别上皮内瘤变的临床效果理想,可提高病变的逆转率,避免内镜下各种微创疗法的过度治疗,且有效控制食管癌的发生。Objective To observe clinical effect of modified Shenzhe Peiqi Decoction in the treatment of esophageal low grade intraepithelial neoplasia.Methods Fifty patients with esophageal low grade intraepithelial neoplasia from January2017 to January 2018 in the Outpatient and Inpatient of Spleen and Stomach Department of Huanggang Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine were selected and divided into control group and treatment group by using random number table method,with 25 cases in each group.Control group was given Western medicine to inhibit acid and protect stomach.Treatment group was given modified Shenzhe Peiqi Decoction orally for 8 weeks.Before treatment and 1,2,4 and 8 weeks after treatment,total score of traditional Chinese medicine syndrome rating scale was used to determine the curative effect of traditional Chinese medicine syndrome.At the end of the course of treatment,4 weeks after the drug was stopped,electronic gastroscopy was performed again.The endoscopic and histopathological manifestations were statistically analyzed,and the improvement degree of pathological manifestations and total scores were calculated.All patients were followed up for 24 weeks to find out whether there was any change of the condition.Results The effects of traditional Chinese medicine syndrome,endoscopic esophageal mucosa and histopathology in treatment group were better than those in control group,the differences were statistically significant(P<0.05).Conclusion Modified Shenzhe Peiqi Decoction has an ideal effect in the treatment of esophageal low grade intraepithelial neoplasia,it can improve the reversal rate of esophageal low grade intraepithelial neoplasia,avoid excessive treatment of various minimally invasive therapies under endoscope,and effectively control the occurrence of esophageal cancer.

关 键 词：参赭培气汤 食管 低级别上皮内瘤变 疗效 

分 类 号：R256.3[医药卫生—中医内科学]