IFN-γ、IL-6、sIL-2R在初治型肺结核患者血清中的变化意义研究  

Study on the significance of serum levels of IFN-γ、IL-6 and sIL-2R in patients with primary pulmonary tuberculosis

作　　者：张信鸽 刘新[2] 赵丹晖 ZHANG Xinge;LIU Xin;ZHAO Danhui(Nanyang tuberculosis control center,Nanyang,Henan,China,473000;Department of tuberculosis,Henan Chest Hospital,Zhengzhou,Henan,China,450000;Department of Pathology,Xi'an Xijing Hospi-tal,Xi'an,Shanxi,China,710000)

机构地区：[1]南阳市结核病防治所结核病区,河南南阳473000 [2]河南省胸科医院结核科,河南郑州450000 [3]西安西京医院病理科,陕西西安710000

出　　处：《分子诊断与治疗杂志》2020年第6期777-780,共4页Journal of Molecular Diagnostics and Therapy

摘　　要：目的探讨痰菌阳性的初治型肺结核患者血清干扰素γ(IFN-γ)、白细胞介素-6(IL-6)、可溶性白介素-2受体(s IL-2R)水平及意义。方法选取2017年2月至2018年10月在本院治疗的初治型肺结核患者142例(观察组),同时选取健康志愿者120例作为对照组,观察组采用2HREZ/10HR方案治疗,检测治疗前及治疗两个月后血清IFN-γ、IL-6、sIL-2R水平,观察强化治疗前后血清IFN-γ、IL-6、sIL-2R水平变化及痰菌转阴情况,并绘制ROC曲线,评估IFN-γ、IL-6、sIL-2R对痰菌转阴的预测价值。结果观察组血清sIL-2R、IL-6、IFN-γ水平明显高于对照组,差异有统计学意义(P<0.05);治疗两个月后观察组患者IFN-γ、IL-6、s IL-2R水平均较治疗前降低,差异有统计学意义(P<0.05)。痰菌转阴患者血清s IL-2R、IL-6、IFN-γ水平低于痰菌未转阴患者,差异有统计学意义(P<0.05)。IFN-γ、IL-6、s IL-2R单独及联合检测预测痰菌转阴的AUC值分别为0.845、0.791、0.745、0.918。结论初治型肺结核患者血清IFN-γ、IL-6、sIL-2R水平明显升高,与结核的活动有关,痰菌转阴后IFN-γ、IL-6、sIL-2R水平明显下降,痰菌阳性肺结核患者联合检测IFN-γ、IL-6、sIL-2R水平有助于对痰菌转阴情况进行评估。Objective To investigate the serum levels of interferon-γ(IFN-γ),interleukin-6(IL-6)and soluble interleukin-2 receptor(sIL-2R)in primary pulmonary tuberculosis patients with positive sputum bacteria.Methods 142 patients(observation group)were selected for the initial treatment of pulmonary tu-berculosis in our hospital from February 2017 to October 2018,and 120 healthy volunteers were selected as the control group.The observation group was treated with 2HREZ/10HR scheme.The levels of serum IFN-γ,IL-6 and sIL-2R in treatment before and 2 months after treatment were measured to observe the changes of serum IFN-γ,IL-6,sIL-2R and the sputum bacteria turning negative before and after intensive treatment The ROC curve was drawn to evaluate the predictive value of IFN-γ,IL-6 and sIL-2R for the sputum bacteria turning negative.Result The serum levels of sIL 2R,IL-6 and IFN-γin the observation group were significantly higher than those in the control group,and the differences had statistical significance(P<0.05).The levels of IFN-γ,IL-6 and SIL-2R after two months of treatment in the observation group were significantly lower than those in treatment before(P<0.05).The serum levels of sIL 2R,IL-6 and IFN-γin patients with the negative turning of sputum bacteria were lower than those in patients with no negative turning of sputum bacteria,and the differences had statistical significance(P<0.05).The AUC values of IFN-γ,IL-6 and SIL-2R with alone and combined detection to predictg the negative turning of sputum bacteria were 0.845、0.791、0.745 and 0.918 respectively.Conclusion Serum levels of IFN-γ,IL-6 and sIL-2R in the serum of the patients with primary pulmonary tuberculosis were significantly increased,which was related to the activity of tuberculosis.The levels of IFN-γ,IL-6 and sIL-2R were significantly decreased after the sputum bacteria turned negative.The combined detection of IFN-γ,IL-6 and SIL-2R in the patients with sputum bacteria positive pulmonary tuberculosis was helpful to evaluate the sputum b

关 键 词：肺结核 干扰素Γ 白细胞介素-6 可溶性白介素-2受体 

分 类 号：R521[医药卫生—内科学]