益气固肾汤加减联合西药治疗肾病综合征30例  

Thirty Cases of Nephrotic Syndrome Treated with Modified Qi-Boosting and Kidney-Strengthening Decoction in Combination with Western Medicine

作　　者：耿玉安 师延刚 许智晶 齐路 崔震宇 刘瑞芳 GENG Yu-an;SHI Yan-gang;XU Zhi-jing;QI Lu;CUI Zhen-yu;LIU Rui-fang(The Third People's Hospital Directly Under Henan Province,Zhengzhou,Henan,China,450006)

机构地区：[1]河南省直第三人民医院,河南郑州450006

出　　处：《河南中医》2020年第7期1054-1057,共4页Henan Traditional Chinese Medicine

基　　金：河南省科技攻关计划项目(2018020580)。

摘　　要：目的:观察益气固肾汤加减联合西药治疗肾病综合征的临床疗效。方法:将60例肾病综合征患者按照随机数字表法分为对照组和研究组,每组各30例。对照组给予常规西药治疗,研究组在对照组的基础上加用益气固肾汤加减治疗。比较两组患者治疗前后中医证候积分变化情况,检测两组患者治疗前后血脂水平[三酰甘油(total triglycerides,TG)、高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)、总胆固醇(Total Cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein chesterol,LDL-C)]及肾功能[24小时尿蛋白、血白蛋白、血尿素氮(blood urea nitrogen,BUN)、血清肌酐(serum creatinine,SCr)]。结果:两组患者治疗后中医证候积分低于本组治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后TG、HDL-C、TC、LDL-C水平低于本组治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后24小时尿蛋白、BUN、SCr低于本组治疗前,且研究组低于对照组,两组患者治疗后血白蛋白高于本组治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。研究组不良反应发生率为6.67%,对照组为26.67%,差异有统计学意义(P<0.05)。结论:益气固肾汤加减联合西药可有效降低肾病综合征患者中医证候积分,降低24小时尿蛋白水平,提高血白蛋白水平,改善血脂水平及肾功能。Objective:To observe the clinical curative effect of Modified Qi-Boosting and Kidney-Strengthening Decoction in combination with Western medicine on nephrotic syndrome.Methods:A total of 60 patients with nephrotic syndrome were divided into the control group and the study group according to the random number table method,with 30 cases in each group.The control group was treated with conventional western medicine,while the study group was treated with Modified Qi-Boosting and Kidney-Strengthening Decoction on the basis of the control group.The changes of TCM syndrome score before and after the treatment were compared between the two groups,and the blood lipid levels,including total triglycerides(TG),high density liptein cholesterol(HDL-C),total cholesterol(TC),and low density lipoprotein chesterol(LDL-C),and renal function,including 24-hour urinary protein,albumin,blood urea nitrogen(BUN),serum creatinine(SCR)were measured before and after the treatment.Results:After the treatment,the TCM syndrome score of each group was lower than that of the same group before the treatment,and the TCM syndrome score of the study group was lower than that of the control group,and the difference between the two groups was statistically significant(P<0.05).The levels of TG,HDL-C,TC and LDL-C of each group were lower than those of the same group before the treatment,and the above indexes of the study group were lower than those of the control group,and all the differences between the two groups were statistically significant(P<0.05).The 24-hour urine protein,BUN and SCr of each group were lower than those of the same group before the treatment,and the above indexes of the study group were lower than those of the control group;the serum albumin of each group was higher than that of the same group before the treatment,and the above index of the study group was higher than that of the control group,and all the differences between the two groups were statistically significant(P<0.05).The incidence of adverse reactions was 6.67%in the st

关 键 词：肾病综合征 益气固肾汤加减 呋塞米注射液 低分子肝素钙 双嘧达莫片 辛伐他汀片 醋酸泼尼松龙片 

分 类 号：R277.592[医药卫生—中医学]