壳聚糖改性蒙脱石作为药物控释载体的研究  

Study on Chitosan Modified Montmorillonite as Drug Controlled-Release Carrier

作　　者：彭琪[1] 葛莹莹 陈琳 经梦丽 PENG Qi;GE Yingying;CHEN Lin;JING Mengli(College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang 464000, China;Department of Pharmacy, Xinyang Central Hospital, Xinyang 464000, China)

机构地区：[1]信阳师范学院化学化工学院,信阳464000 [2]信阳市中心医院药剂科,信阳464000

出　　处：《硅酸盐通报》2020年第6期1980-1984,共5页Bulletin of the Chinese Ceramic Society

基　　金：河南省科技计划项目(162102210403)。

摘　　要：采用壳聚糖(CS)对钠基蒙脱石(MMT)进行改性制备有机蒙脱石(CS-MMT),对改性后的蒙脱石进行红外光谱(FT-IR)和X射线衍射(XRD)等分析表征。以5-氟尿嘧啶(5-FU)为药物模型制备出壳聚糖改性蒙脱石载药复合物(5-FU/CS-MMT),并以钠基蒙脱石载药复合物(5-FU/MMT)作为对照,探究载药复合物在模拟人工胃液、人工小肠液和人工结肠液中的药物释放情况。结果表明,当CS的用量是MMT的1.0倍阳离子交换容量时,形成的有机蒙脱石的层间距增大,且对5-FU的载药量达到393 mg/g,而同等情况下,MMT的载药量为239 mg/g。体外释放试验的结果表明,5-FU/CS-MMT中5-FU的体外释放能力主要受释放介质pH值的影响,当pH值为7.4时,5-FU的累积释放率最大,在pH值为1.5时的结果最小。Chitosan(CS)was used to modify montmorillonite(MMT)to prepare organized montmorillonite(CS-MMT).The structure of modified montmorillonite was characterized by infrared spectroscopy(FT-IR)and X-ray diffraction(XRD).The chitosan modified montmorillonite carriers(5-FU/CS-MMT)were prepared by using 5-fluorouracil(5-FU)as a drug model.The drug release in simulated artificial gastric juice,intestinal fluid and colon fluid was explored by using sodium montmorillonite as a control.The results show that the layer spacing of organic montmorillonite increases when the amount of CS is equivalent to one fold of MMT′s cation exchange capacity.The loaded dosage of CS-MMT is 393 mg/g,and the dosage of MMT is 239 mg/g.The results of in vitro release experiments show that the in vitro release ability of 5-FU in 5-FU/CS-MMT is mainly affected by the pH value of the release medium.At pH 7.4,the cumulative release rate of 5-FU is the largest,and at pH 1.5 the release rate is the smallest.

关 键 词：蒙脱石 壳聚糖 改性 5-氟尿嘧啶 载体 

分 类 号：O647.32[理学—物理化学]