基于复杂网络分析的实证亚健康人群233例样本证候要素与体检指标关联研究  

Correlation between TCM syndrome elements and physical examination indexes: study on 233 excess syndrome cases of sub-health status based on complex network analysis

作　　者：崔龙涛[1] 许家佗[1] 李军[1] 石玉琳 屠立平[1] CUI Longtao;XU Jiatuo;LI Jun;SHI Yulin;TU Liping(Fei Zhaofu Prestigious Professor Research Office,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学费兆馥名师研究室,上海201203

出　　处：《上海中医药杂志》2020年第6期58-65,共8页Shanghai Journal of Traditional Chinese Medicine

基　　金：科技部“十三五”国家重点研发计划中医药现代化研究重点专项(2017YFC1703301);国家自然科学基金项目(81873235,81973750,81904094);1226工程科技重点项目(BWS17J028);上海市卫健委进一步加快中医药事业发展三年行动计划项目[ZY(2018-2020)-CCCX-2001-01]。

摘　　要：目的通过复杂网络分析获取实证亚健康人群的核心中医证候要素和西医体检指标,为辨别亚健康人群的中医实证证候提供更多维度的临床依据和可靠方法。方法按照健康状态分类方法,筛选亚健康人群属实证者233例,其中气滞证105例,血瘀证69例,痰湿证34例,实热证25例;运用复杂网络分析方法,分析每个证型的证候要素与西医体检指标之间核心的网络关系。结果①气滞证人群的核心证候要素为胃脘闷胀、胸胁胀痛、厚苔等;核心西医体检指标为舒张压异常、单核细胞水平异常;两组项目的关联节点为胃脘闷胀、嗳气、厚苔、疲倦、舒张压异常。②血瘀证人群的核心证候要素为淡紫舌、白苔、脉象左细等;核心西医体检指标为收缩压异常、嗜碱性粒细胞水平异常、血小板分布宽度异常等;两组项目的关联节点为淡紫舌、白苔、脉象左弦、脉象左细、收缩压异常、舒张压异常、嗜碱性粒细胞水平异常、血小板分布宽度异常、单核细胞水平异常。③痰湿证人群的核心证候要素为腻苔、头晕、失眠等;核心西医体检指标为体质量指数异常、尿酸异常、总胆固醇异常等;两组项目的关联节点为黄苔、厚苔、腻苔、收缩压异常、单核细胞水平异常、血小板分布宽度异常、体质量指数异常。④实热证人群的核心证候要素为齿龈肿痛、黄苔、便秘等;核心西医体检指标为体质量指数异常、收缩压异常、单核细胞水平异常等;两组项目的关联节点为便秘、黄苔、收缩压异常、舒张压异常、嗜碱性粒细胞水平异常、单核细胞水平异常。结论运用复杂网络方法可以发现亚健康实证不同证型人群的核心证候要素和核心西医体检指标,为亚健康人群实证辨证提供更准确、更多维度的依据;不同中医证型对应的特异性体检指标有助于从西医视角发现实证亚健康人群的异常表现,进�Objective To obtain the core traditional Chinese medicine(TCM)syndrome elements and western medicine physical examination indexes of sub-health population through complex network analysis,and to provide multi-dimensional clinical basis and reliable methods for distinguishing TCM excess syndromes in sub-health population.Method According to the classification criteria of health status,we screened 233 cases of sub-health status diagnosed with TCM excess syndrome,including 105 cases of qi stagnation syndrome,69 cases of blood stasis syndrome,34 cases of phlegm-dampness syndrome and 25 cases of excess heat syndrome.The complex network analysis was used to analyze the core network relationship between TCM syndrome elements of each syndrome and western medicine physical examination indexes.Results(1)The core syndrome elements of Qi stagnation syndrome were epigastric stuffiness and distension,distending pain of chest and hypochondrium and thick coating,etc.The core physical examination indexes of western medicine were abnormal diastolic blood pressure and monocyte level.The associated nodes of the two groups of items were epigastric stuffiness and distension,belching,thick coating,fatigue and abnormal diastolic blood pressure.(2)Thecore syndrome elements of blood stasis syndrome were pale purple tongue,white coating and thin left pulse,etc.The core physical examination indexes of western medicine were abnormal systolic blood pressure,basophil level and platelet distribution width,etc.The associated nodes of the two groups of items were pale purple tongue,white coating,wiry left pulse,thin left pulse,abnormal systolic blood pressure,diastolic blood pressure,basophilic granulocyte level,platelet distribution width and monocyte level.(3)The core syndrome elements of phlegm-dampness syndrome were greasy coating,dizziness and insomnia,etc.The core physical examination indexes of western medicine were abnormal body mass index(BMI),uric acid and total cholesterol,etc.The associated nodes of the two groups of items were yellow

关 键 词：亚健康人群 复杂网络 中医证候 实证 体检指标 

分 类 号：R259[医药卫生—中西医结合]