生理浓度血清胆红素水平对慢性阻塞性肺疾病急性加重的预测价值  

Predictive value of physiological concentration of serum bilirubin on acute exacerbation of chronic obstructive pulmonary disease

作　　者：关日辉 孙杰 吴东 黄丹 GUAN Ri-hui;SUN Jie;WU Dong;HUANG Dan(Guangdong Medical University,Zhanjiang 524023,China;Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)

机构地区：[1]广东医科大学,广东湛江524023 [2]广东医科大学附属医院,广东湛江524001

出　　处：《广东医科大学学报》2020年第3期297-300,共4页Journal of Guangdong Medical University

摘　　要：目的 探讨生理浓度血清胆红素水平变化对慢性阻塞性肺疾病急性加重(AECOPD)的预测价值.方法 201例AECOPD患者根据1a内急性加重事件的发生频率分为频繁加重组(加重次数≥2)和非频繁加重组(加重次数<2),分析血清胆红素水平与AECOPD事件的关系.结果 频繁急性加重组血清总胆红素、直接胆红素及间接胆红素水平均高于非频繁急性加重组(P<0.01).血清间接胆红素预测COPD频繁急性加重事件的ROC曲线面积AUC为0.708,大于血清总胆红素(0.707)和血清直接胆红素(0.663)(P<0.05).结论 生理浓度血清胆红素水平与COPD频繁急性加重的危险性呈负相关,其中血清间接胆红素对COPD急性加重事件的发生有一定的预测价值.Objective To investigate the predictive value of physiological concentration of serum bilirubin on acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods Based on frequency of acute exacerbation during 1 year, 201 AECOPD patients were divided into frequent exacerbation(frequency ≥2) and infrequent exacerbation(frequency <2) groups. The relationship between serum bilirubin levels and AECOPD was analyzed. Results Serum levels of total bilirubin(TBIL), direct bilirubin(DBIL) and indirect bilirubin(IBIL) were higher in frequent exacerbation group than in infrequent exacerbation group(P<0.01). The area under ROC curve(AUC) of IBIL was 0.708 for predicating frequent exacerbation of COPD, which was superior to that of TBIL(0.707) and DBIL(0.663)(P<0.05). Conclusion The physiological level of serum bilirubin is negatively correlated with the frequency of AECOPD. Serum IBIL content might forecast the occurrence of AECOPD.

关 键 词：慢性阻塞性肺疾病急性加重 胆红素 

分 类 号：R563[医药卫生—呼吸系统]