α-烯醇化酶蛋白抗原的表达与血管相关疾病及肿瘤发生的关系  

Relationship between expression ofα-enolase protein antigen and vascular diseases and tumorigenesis

作　　者：刘逸夫 卢一寒 李静[1] LIU Yi-Fu;LU Yi-Han;LI Jing(The First Hospital of China Medical University,Shenyang 110000,China)

机构地区：[1]中国医科大学附属第一医院,沈阳110000

出　　处：《中国免疫学杂志》2020年第12期1508-1511,共4页Chinese Journal of Immunology

基　　金：国家重点研发计划(No.2017YFC0907403);国家科技部精准医学研究重点专项项目(东北区域母胎-儿童-青少年队列研究,No.2017YF0907403);国家自然科学基金面上项目(No.81771741);辽宁省教育厅第四批辽宁特聘教授人才项目(辽教发2014-187号)资助。

摘　　要：α-烯醇化酶(ENO1)参与血管相关疾病的发生发展以及恶性肿瘤细胞的演变和转移,尤其在血管内皮的促炎激活、功能障碍以及自身免疫病微小血管的损害过程发挥重要作用。本文从4个方面分别综述:血管内皮细胞及相关免疫细胞表面的ENO1参与介导炎症活化,引发血管相关疾病;在低氧条件下,HIF-1α通过诱导ENO1表达参与血管生成;ENO1通过翻译后修饰参与血管相关疾病发生发展;ENO1作为毒性因子增加血管的通透性引起血管相关疾病。α-enolase(EN01)is involved in development of vascular-related diseases and evolution and metastasis of malignant tumor cells,especially in proinflammatory activation,dysfunction of vascular endothelium and microvascular damage in autoimmune diseases.This article reviews from four aspects:ENO1 on surface of vascular endothelial cells and related immune cells is involved in mediating inflammatory activation,causing vascular-related diseases.Under hypoxic conditions,HIF-1αparticipates in angiogenesis by inducing expression of ENO1;ENO1 participates in development of vascular related diseases through post-translational modification and ENO1;As a toxic factor,ENO1 increases vascular permeability and causes vascular related diseases.

关 键 词：烯醇化酶 内皮细胞 炎症活化 低氧诱导因子 

分 类 号：R392.12[医药卫生—免疫学]