3.0T磁共振化学位移技术定量胰腺脂肪沉积与2型糖尿病的相关性研究  

Correlation between pancreatic fat deposit quantified by 3.0T magnetic resonance chemical shift technology and type 2 diabetes mellitus

作　　者：段秀苹 雷燕[2] 唐伟[1] 李兴辉[1] 翟昭华[1] 张小明[1] Duan Xiuping;Lei Yan;Tang Wei;Li Xinghui;Zhai Zhaohua;Zhang Xiaoming(Sichuan Key Laboratory of Medical Imaging,Department of Radiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Sichuan Key Laboratory of Medical Imaging,Clinical Laboratory,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]四川省医学影像重点实验室,川北医学院附属医院放射科,四川南充637000 [2]四川省医学影像重点实验室,川北医学院附属医院检验科,四川南充637000

出　　处：《中华消化病与影像杂志（电子版）》2020年第2期74-79,共6页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

基　　金：四川省教育厅基金一般项目资助(16ZB0232)。

摘　　要：目的探讨磁共振化学位移技术定量胰腺脂肪沉积在2型糖尿病与血糖正常者之间的差异,以及胰腺脂肪沉积与2型糖尿病的相关性。方法回顾性分析接受上腹部3.0T MRI检查的66例2型糖尿病患者和84例血糖正常患者的临床病历资料及脂肪代谢生化指标,在同相位和反相位序列图像上分别测量2型糖尿病组和血糖正常组的胰腺脂肪含量百分比。分析2型糖尿病组和血糖正常组的胰腺脂肪含量的差异,以及分别与年龄、性别、体质量指数及脂肪代谢生化指标的相关性。结果2型糖尿病组胰腺平均脂肪分数和胰头、胰体、胰尾脂肪分数分别为3.7~10.56%、2.34~11.08%、2.25~11.33%、2.34~13.46%,血糖正常组胰腺平均脂肪分数和胰头、胰体、胰尾脂肪分数分别为2.4~7.46%、1.38~7.88%、0.77~8.59%、1.38~9.58%;2型糖尿病组平均胰腺脂肪分数(t=4.371,P=0.000)和胰头(t=3.231,P=0.002)、胰体(t=3.052,P=0.003)、胰尾(t=2.962,P=0.004)的脂肪分数高于血糖正常组。2型糖尿病组的脂肪代谢指标甘油三酯(t=2.614,P=0.010)、极低密度脂蛋白胆固醇(t=2.271,P=0.025)高于血糖正常组,高密度脂蛋白胆固醇(t=-2.560,P=0.011)低于血糖正常组。2型糖尿病组脂肪含量与年龄(r=0.366,P=0.003)、体质量指数(r=0.303,P=0.013)呈正相关。结论2型糖尿病组胰腺脂肪分数明显高于血糖正常组,表明胰腺脂肪沉积与2型糖尿病密切相关,可能是2型糖尿病的潜在危险因素。Objective To investigate the quantitative difference of pancreatic fat fraction(PFF)in patients with type 2 diabetes mellitus(T2DM)and normal blood glucose(NBG)by magnetic resonance chemical shift technique,and the correlation between pancreatic fat deposition and T2DM.Methods The clinical data and biochemical indexes of fat metabolism of 66 patients with T2DM and 84 patients with NBG who underwent 3.0T MRI examination of the upper abdomen were analyzed retrospectively.The percentages of pancreatic fat content(PFC)in T2DM group and NBG group were measured on both in-phase and opposed-phase sequence images.The difference of PFC was analyzed between T2DM group and NBG group,as well as the correlation with age,gender,body mass index(BMI)and biochemical indexes of fat metabolism.Results The average PFF,and focal PFF of pancreatic head,body and tail were 3.7%-10.56%,2.34%-11.08%,2.25%-11.33%and 2.34%-13.46%in T2DM group,and 2.4%-7.46%,1.38%-7.88%,0.77%-8.59%and 1.38%-9.58%in NBG group.The average PFF(t=4.371,P=0.000),focal PFF of pancreatic head(t=3.231,P=0.002),focal PFF of pancreatic body(t=3.052,P=0.003),focal PFF of pancreatic tail(t=2.962,P=0.004)in T2DM group were significantly higher than those in NBG group.The triglycerides(t=2.614,P=0.010)and very low-density lipoprotein cholesterol(t=2.271,P=0.025)in T2DM group were higher than those in NBG group.The high density lipoprotein cholesterol(t=-2.560,P=0.011)in T2DM group was lower than that in NBG group.PFC of T2DM group was positively correlated with age(r=0.366,P=0.003)and BMI(r=0.303,P=0.013).Conclusion The PFF in T2DM group is significantly higher than that in NBG group,which indicates that the fat deposition of pancreas is closely related to T2DM and may be a potential risk factor for T2DM.

关 键 词：糖尿病 2型 胰腺 脂肪沉积 磁共振成像 化学位移成像 

分 类 号：R58[医药卫生—内分泌]