匹莫范色林的合成  

Synthesis of Pimavanserin

作　　者：李梦兰 李文燕 李爽 代文双(指导)[1] LI Meng-lan;LI Wen-yan;LI shuang;DAI Wen-shuang(School of biomedical and Chemical Engineering,Liaoning Institute of Science and Technology,Liaoning Benxi 117004,China;Tangshan Aitai Oil Detection co.,Ltd,Hebei Tangshan 06300)

机构地区：[1]辽宁科技学院生物医药与化学工程学院,辽宁本溪117004 [2]唐山爱特爱油液检测有限公司,河北唐山063000

出　　处：《辽宁科技学院学报》2020年第3期14-16,共3页Journal of Liaoning Institute of Science and Technology

基　　金：2019年辽宁科技学院大学生创新创业训练项目(201911430019).

摘　　要：对羟基苯甲醛和异丁基溴为起始原料经过取代、正向肟化、加氢等合成4-异丁氧基苄胺,再与4-氟苄胺和N-甲基-4-哌啶酮经还原胺化反应合成的N-(4-氟苄基)-N-1-甲基哌啶胺反应得到匹莫范色林,总收率达到64%。合成方法反应条件温和,成本低廉,安全环保。In this paper,pimavanserin is synthesized by 4-Isobutoxybenzylamine and N-(4-fluoro benzyl)-N-1-methyperidol.4-isobutylbenzaldehyde and isobutylbromine are selected as starting materials to synthesize 4-Isobutoxybenzylamine and its acetate through substitution,forward oxime and hydrogenation.N-(4-fluoro benzyl)-N-1-methyperidol is synthesized by condensation reaction with N-methyl-4-piperidine and 4-flubenzylamine as raw materials.and the reaction rate reached 64%.The synthesis method in this paper has the advantages of mild reaction conditions,low cost,safety and environmental protection.

关 键 词：匹莫范色林 对羟基苯甲醛 4-氟苄胺 合成 

分 类 号：TQ031.2[化学工程]