氮硫共掺杂碳量子点对胃液pH值的精确检测  

Nitrogen and Sulfur co-Doped Carbon Quantum Dots for Accurate Detection of pH in Gastric Juice

作　　者：黄加玲 刘凤娇 王婷婷[1] 刘翠娥 郑凤英 王振红 李顺兴[1,2] HUANG Jialing;LIU Fengjiao;WANG Tingting;LIU Cuie;ZHENG Fengying;WANG Zhenhong;LI Shunxing(College of Chemistry,Chemical Engineering and Environment,Minnan Normal University,Zhangzhou 363000,China;Fujian Province Key Laboratory of Modern Analytical Science and Separation Technology&Pollution Monitoring and Control,Minnan Normal University,Zhangzhou 363000,China)

机构地区：[1]闽南师范大学化学化工与环境学院,漳州363000 [2]闽南师范大学现代分离分析科学与技术福建省重点实验室&污染监测与控制福建省高校重点实验室,漳州363000

出　　处：《高等学校化学学报》2020年第7期1513-1520,共8页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21675077);福建省高校产学合作项目(批准号:2019Y4010);福建省高等学校新世纪优秀人才支持计划资助.

摘　　要：以水杨酸和硫脲为原料,通过水热法一步合成水溶性好、稳定性强、量子产率高(36.23%)、呈蓝光的氮硫共掺杂碳量子点(N,S-CQDs).在302 nm波长激发下,N,S-CQDs在发射波长409 nm处的荧光强度与pH值(在2.01~5.11范围内)线性关系良好,相关系数为0.9931,可原位、实时检测胃液内pH值在Δ0.01范围内的变化.可用于胃癌早期诊断和新生儿健康防护.400μg/m L N,S-CQDs孵育铜绿微囊藻细胞48 h,存活率82.8%,其可作为人体胃细胞荧光探针,经人体排泄进入水环境,对淡水浮游生物毒性低,环境友好.Nitrogen-sulfur co-doped carbon quantum dots with blue light,good water solubility,strong stability and high quantum yield(36.23%),were synthesized by one-step hydrothermal method,using salicylic acid and thiourea as raw materials.Under the excitation of 302 nm,there is a good linear relationship between the fluorescence intensity and the pH value in the range of 2.01-5.11 at the emission wavelength of 409 nm,and the correlation coefficient is 0.9931.The change of pH value in gastric juice can be detected in situ and in real time.In view of the fact that the pH value of gastric juice is closely related to the diagnosis of gastric cancer and neonatal monitoring,N,S-CQDs are expected to contribute to the early diagnosis of gastric cancer and neonatal health protection.N,S-CQDs have low cytotoxicity and good biocompatibility.When microcystis aeruginosa cells as phytoplankton model are incubated with 400μg/mL of N,S-CQDs for 48 h,their survival ratesare 82.8%,indicating that N,S-CQDs could be used as a environmental-friendly fluorescent probe for human gastric cells.

关 键 词：碳量子点 掺杂 PH值 胃液 荧光探针 

分 类 号：O655[理学—分析化学]