沙格列汀对早期2型糖尿病患者胰腺功能的改善作用  

The Improvement of Pancreatic Function in Patients with Early Type 2 Diabetes Mellitus

作　　者：李婷婷 LI Tingting(Emergency Department,Liaoyoubaoshihua Hospital,Panjin 124000.Liaoning Province,China)

机构地区：[1]盘锦辽油宝石花医院急诊科,辽宁盘锦124000

出　　处：《中国实用乡村医生杂志》2020年第6期44-46,共3页Chinese Practical Journal of Rural Doctor

摘　　要：目的探讨沙格列汀对早期2型糖尿病(T2D M)患者胰腺功能的改善作用.方法收集2019年1—12月盘锦辽油宝石花医院收治的T2D M患者110例,随机分为对照组和观察组各55例.对照组采用胰岛素泵强化治疗,观察组在其基础上加用沙格列汀治疗,比较两组治疗后血糖、胰腺分泌和胰岛素抵抗改善情况.结果两组经治疗后,T2时间点C肽(CP)和β细胞功能指数、胰岛素抵抗指数组间差异均有统计学意义(P<0.05).结论沙格列汀能够提高早期T2DM患者第二时相胰岛素分泌能力,并且进一步缓解胰岛素抵抗状态.Objective To investigate the effect of sagletin in the improvement of pancreatic function in patients with early type 2 diabetes mellitus(T2DM)by.Methods A total of 110 T2DM patients admitted to our hospital from January to December 2019 were randomly divided into control group and observation group with 55 cases each.The control group was treated with intensive insulin pump,and the observation group was treated with saggliptin on the basis of it.The improvement of blood glucose,pancreatic secretion and insulin resista nee were compared between the two groups after treatment.Results After treatment,there were significant differences in CP level,beta cell fiinction index and insulin resistant indices at T2 time point between the two groups(P<0.05).Conclusion Sagletin can improve the second phase insulin secretion in early T2DM patients,and further alleviate the state of insulin resistance.

关 键 词：糖尿病 2型 沙格列汀 胰岛素 胰腺 内分泌 

分 类 号：R587.1[医药卫生—内分泌]