硝普钠治疗风湿性心脏病并发心衰患者的临床效果研究  

Clinical Effect of Sodium Nitroprusside on the Rheumatic Heart Disease Patients Complicated with Heart Failure

作　　者：魏莉娜[1] 王月平[1] 朱秋霞 任星星 贾利清[1] WEI Li-na;WANG Yue-ping;ZHU Qiu-xia;REN Xing-xing;JIA Li-qing(Department of Cardiovascular Medicine,the Third Affiliated Hospital of Inner Mongolia Medical University,Baotou,Inner Mongolia,014010,China)

机构地区：[1]内蒙古医科大学第三附属医院心血管内科,内蒙古包头014010

出　　处：《现代生物医学进展》2020年第10期1885-1888,共4页Progress in Modern Biomedicine

基　　金：内蒙古自治区自然科学基金项目(2018MS08130)。

摘　　要：目的:探讨硝普钠治疗风湿性心脏病并发心衰患者的临床效果及安全性。方法:选取内蒙古医科大学第三附属医院2016-2019年收治的80例风湿性心脏病并发心衰患者,将其随机分为研究组和对照组,每组40例。对照组采取常规治疗,研究组在此基础上应用硝普钠治疗,对比两组治疗前后心脏血流动力学参数、舒张压、收缩压、心率、呼吸的变化、临床效果及不良反应的发生情况。结果:两组治疗后左心室收缩末期内径(Left ventricular end-systolic diameter,LVESD)、左房内径(left atrial diameter,LAD)、左心室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)均较治疗前明显降低,左室射血分数值(left ventricular ejection fraction,LVEF)均明显高于治疗后(P<0.05),且研究组上述指标的改善程度均明显优于对照组(P<0.05)。研究组治疗后舒张压、收缩压、心率、呼吸低于对照组(P<0.05);研究组的治疗有效率心脏高于对照组(P<0.05);两组不良反应的发生率比较差异无统计学意义(P>0.05)。结论:硝普钠治疗风湿性心脏病并发心衰患者应可有效改善患者心功能,提高临床治疗效果,具安全性较好。Objective: To investigate the clinical effect and safety of sodium nitroprusside on the rheumatic heart disease patients complicated with heart failure. Methods: Eighty rheumatic heart disease patients complicated with heart failure admitted to the Third Affiliated Hospital of Inner Mongolia Medical University from 2016-2019 were selected as study subjects. They were randomly divided into the study group and the control group, with 40 cases in each group. The control group received routine treatment. The study group was treated with sodium nitroprusside. The hemodynamic parameters, diastolic blood pressure, systolic blood pressure, heart rate, respiratory changes, clinical effects and adverse reactions were compared before and after treatment. Results: After treatment, LVESD, LAD and LVEDD were significantly lower than those before treatment. The LVEF was significantly higher than that after treatment(P<0.05), and the improvement of the above indexes in the study group was significantly better than that of the control group(P<0.05). The study group was treated with diastolic blood pressure, systolic blood pressure, heart rate, and respiration lower than that of the control group(P<0.05).The effective rate of the study group was significantly higher than that of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Rheumatic heart disease patients complicated with heart failure have significant therapeutic effects with sodium nitroprusside, which can effectively improve the heart function of patients,and have better safety.

关 键 词：风湿性心脏病 心力衰竭 硝普钠 治疗效果 

分 类 号：R541.2[医药卫生—心血管疾病] R541.61[医药卫生—内科学]