子宫腺肌病患者血清NGF、PTGFR、β-EP水平和与痛经强度的相关性研究  

Correlation of Serum Levels of NGF,PTGFR andβ-EP with the Dysmenorrhea Intensity of Patients with Adenomyosis of Uterus

作　　者：纪利娜 梁紫影 张秀艳 胡媛 岳琳 JI Li-na;LIANG Zi-ying;ZHANG Xiu-yan;HU Yuan;YUE Lin(Chengde Central Hospital(Second Clinical College of Chengde Medical College),Department of Gynecology,Chengde,Hebei,067000,China;Chengde Central Hospital(Second Clinical College of Chengde Medical College),Department of Ultrasound Diagnosis,Chengde,Hebei,067000,China;Chengde Central Hospital(Second Clinical College of Chengde Medical College),Department of Stomatology,Chengde,Hebei,067000,China)

机构地区：[1]承德市中心医院(承德医学院第二临床学院)妇科,河北承德067000 [2]承德市中心医院(承德医学院第二临床学院)超声诊断科,河北承德067000 [3]承德市中心医院(承德医学院第二临床学院)口腔科,河北承德067000

出　　处：《现代生物医学进展》2020年第10期1970-1974,共5页Progress in Modern Biomedicine

基　　金：承德市科技计划项目(201701A019)。

摘　　要：目的:探讨子宫腺肌病患者血清神经生长因子(NGF)、前列腺素F2α受体(PTGFR)、β-内啡肽(β-EP)水平和与痛经强度的相关性。方法:选择2018年1月至2019年10月我院收治的子宫腺肌病患者80例作为观察组,并选择同期于我院接受健康体检的80例无痛经、月经正常者作为对照组。比较两组一般资料、血清NGF、PTGFR、β-EP水平,及观察组不同痛经强度患者血清NGF、PTGFR、β-EP水平,进一步分析血清NGF、PTGFR、β-EP水平和痛经强度的相关性。结果:两组年龄、身体质量指数(BMI)、孕次、月经周期比较差异无统计学意义(P>0.05),观察组经期天数明显长于对照组[(7.16±0.68)d vs.(5.92±0.60)d](P<0.05);观察组血清NGF、PTGFR明显高于对照组,β-EP明显低于对照组[(78.24±9.50)ng/L vs.(51.32±5.18)ng/L,(370.69±47.81)ng/mL vs.(95.59±10.42)ng/mL,(130.87±21.26)ng/L vs.(206.63±31.84)ng/L](P<0.05);观察组患者随着痛经强度的增加,血清NGF、PTGFR水平逐渐升高,β-EP水平逐渐降低(P<0.05);Pearson相关性分析显示血清NGF、PTGFR水平和VAS评分呈显著正相关(P<0.05),β-EP和VAS评分呈显著负相关(P<0.05),血清NGF和PTGFR水平呈正相关(P<0.05),血清NGF、PTGFR水平和β-EP分别呈负相关(P<0.05)。结论:子宫腺肌病患者血清NGF、PTGFR的表达明显升高,而β-EP明显降低,和痛经强度之间具有密切相关。Objective: To study the correlation of serum levels of nerve growth factor(NGF), prostaglandin F2α receptor(PTGFR)and β-endorphin(β-EP) with the dysmenorrhea intensity of patients with adenomyosis of uterus. Methods: 80 cases with adenomyosis of uterus admitted from January 2018 to October 2019 in our hospital were selected as the observation group, and 80 cases of normal menstruation and no dysmenorrhea were selected as the control group. The general information, the serum levels of NGF, PTGFR and β-EP between two groups, and serum levels of NGF, PTGFR and β-EP between different dysmenorrhea intensity in the observation group were compared, the correlation of serum levels of NGF, PTGFR, β-EP and dysmenorrhea intensity was further analyzed. Results: There was no significant difference in the age, body mass index(BMI), pregnancy times and menstrual cycle between the two groups(P>0.05);the menstrual days in the observation group was significantly longer than those in the control group [(7.16±0.68)d vs.(5.92±0.60)d](P<0.05);the serum NGF and PTGFR in the observation group were significantly higher than those in the control group, and β-EP was significantly lower than those in the control group [(78.24 ±9.50)ng/L vs.(51.32 ±5.18)ng/L,(370.69 ±47.81)ng/mL vs.(95.59 ±10.42)ng/mL,(130.87±21.26)ng/L vs.(206.63±31.84)ng/L](P<0.05);with the increase of dysmenorrhea intensity, the serum levels of NGF,PTGFR were increased, and the levels of β-EP were decreased in the observation group(P<0.05);the Pearson correlation analysis, there were significant positive correlation between the s serum levels of NGF, PTGFR and VAS scores(P<0.05);there was a significant negative correlation between the β-EP and VAS score(P<0.05);there was a positive correlation between the serum levels of NGF and PTGFR(P<0.05);there was a negative correlation between the serum levels of NGF, PTGFR and β-EP(P<0.05). Conclusion: The expression of serum NGF and PTGFR in patients with adenomyosis of uterus was significantly increased, it’s

关 键 词：子宫腺肌病 痛经 神经生长因子 前列腺F2α受体 Β-内啡肽 

分 类 号：R711.74[医药卫生—妇产科学]