静息态fMRI观察电刺激诱发肢体持续麻木感  

Resting-state fMRI observation of persistent limb numbness induced with electrical stimulation

作　　者：方杰 鲁学婷 刘飞[1] 费家廷 王海宝[1] FANG Jie;LU Xueting;LIU Fei;FEI Jiating;WANG Haibao(Department of Radiology,the first Affliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院放射科,安徽合肥230022

出　　处：《中国医学影像技术》2020年第6期808-812,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(81571308)。

摘　　要：目的采用静息态fMRI(rs-fMRI)比率低频振幅(fALFF)法检测电刺激诱发肢体持续麻木感时脑功能变化,探讨持续性麻木相关脑机制。方法对21名健康成人分别在有无电刺激条件下行rs-fMRI,嘱其对同一脉冲电刺激所致麻木感进行强度评分。以fALFF算法分析有无电刺激下rs-fMRI数据,获得存在显著差异脑区;对电刺激下脑fALFF与个体麻木感强度评分进行相关性分析。结果电刺激下fALFF显著增强脑区包括额叶内侧皮质、前扣带回、两侧颞中回、两侧颞下回和右侧颞极(P均<0.05,FDR校正);显著减弱脑区包括楔前叶/后扣带回、右侧小脑(P均<0.05,FDR校正)。电刺激下fALFF与个体麻木感评分显著正相关脑区则包括楔前叶/后扣带回和左侧颞中回(P均<0.05,FDR校正)显著负相关脑区为右侧额极和左侧颞下回(P均<0.05,FDR校正)。结论电刺诱发肢体持续麻木感涉及感觉运动、情绪、认知及默认网络相关脑区;楔前叶/后扣带回、颞叶及额叶部分脑区与个体麻木程度显著相关。Objective To investigate changes of brain function caused by persistent limb numbness induced with electrical stimulation by using fractional amplitude of low frequency fluctuation(fALFF)of resting-state fMRI(rs-fMRI),and to explore relative brain mechanisms.Methods Totally 21 healthy adults were enrolled.rs-fMRI scans were performed with or without persistent limb numbness induced with electrical stimulation.The subjects were asked to rate the numbness intensity under the same electrical stimulation.fLAFF algorithm was used to analyze rs-fMRI data of brain with and without electrical stimulation.Brain regions with significant differences were acquired,and correlation analysis was performed for fALFF under stimulation and individual numbness intensity scores.Results Brain regions with fALFF increase under electrical stimulation include medial frontal cortex,anterior cingulate cortex,bilateral middle temporal gyrus,bilateral inferior temporal gyrus and right temporal pole(all P<0.05,FDR corrected),those with fALFF decrease included precuneus/posterior cingulate gyrus and right cerebellum(all P<0.05,FDR corrected).Precuneus/posterior cingulate gyrus and left middle temporal gyrus were positively correlated with individual numbness scores(both P<0.05),FDR corrected0,right frontal pole and left inferior temporal gyrus were negatively associated with individual numbness scores(both P<0.05,FDR corrected).Conclusion Persistent limb numbness involves brain regions related to sensorimotor,emotion,cognition and default mode network.Precuneus/posterior cingulate gyrus,temporal lobe and frontal lobe are significantly related to individual numbness.

关 键 词：感觉减退 磁共振成像 电刺激 

分 类 号：R338[医药卫生—人体生理学] R445.2[医药卫生—基础医学]