血清ECP水平与药物洗脱支架晚期支架内再狭窄的相关性  

The relationship between serum eosinophil cationic protein levels and late in-stent restenosis of drug-eluting stents

作　　者：殷嘉晟 蔡思诗 钱菊英 沈雳[1,2] 葛均波 YIN Jia-sheng;CAI Si-shi;QIAN Ju-ying;SHEN Li;GE Jun-bo(Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China;Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院心内科,上海200032 [2]上海市心血管病研究所,上海200032

出　　处：《中国临床医学》2020年第3期406-409,共4页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(81370323,81670319)。

摘　　要：目的:探讨嗜酸性粒细胞阳离子蛋白(eosinophil cationic protein,ECP)与药物洗脱支架(drug eluting stent,DES)晚期支架内再狭窄(in-stent restenosis,ISR)的相关性。方法:选取2014年12月至2016年7月在复旦大学附属中山医院植入DES并超过1年后返院复查造影患者202例,根据复查造影结果分为ISR组(100例)和无ISR组(102例),应用夹心酶联免疫吸附(ELISA)法测定血清ECP水平并比较其在2组间差异。在ISR组和无ISR组,根据支架载药涂层,进一步分为永久涂层-DES组(DP-DES亚组)及可降解涂层-DES组(BP-DES亚组),分析血清ECP水平与载药涂层的关系。结果:ISR组血清ECP水平明显高于无ISR组(P=0.003)。手术年龄和ECP水平是晚期ISR形成的独立危险因素。ISR组DP-DES亚组血清ECP水平高于无ISR组DP-DES亚组(P=0.002)。结论:血清ECP水平在晚期ISR患者中显著升高,可能与支架药物涂层有关。Objective:To explore the relationship between eosinophil cationic protein(ECP)and late in-stent restenosis(ISR)of drug-eluting stent(DES).Methods:Totally,202 patients who underwent angiography follow up beyond 1 year after DES implantation in Zhongshan Hospital,Fudan University from December 2014 to July 2016 were included.Patients were divided into two groups(ISR,n=100 and non-ISR,n=102)according to the results of radiography review one year later.Serum ECP levels were detected by sandwich ELISA and were compared between the two groups.In subgroup analysis,we divided patients into DP-DES and BP-DES groups according to their implanted stent type.Results:Serum ECP levels were significantly higher in the ISR group than in the non-ISR group(P=0.003).Multivariate regression revealed that serum ECP level and age at surgery were independent risk factors for late ISR formation.In sub-group analysis,serum ECP levels was significantly higher in patients with DP-DES in ISR group compared to non-ISR group(P=0.002).Conclusions:Serum ECP levels were higher in patients with late ISR,and its elevation is related to the type of coating drugs on the stent.

关 键 词：支架内再狭窄 嗜酸性细胞阳离子蛋白 药物涂层 

分 类 号：R541[医药卫生—心血管疾病]