甘草饮片炮制工艺的优选  

Optimization of Processing Technology for Radix et Rhizoma Glycyrrhizae Slices

作　　者：赵鑫[1] 张艳雪 李丽 吴鹏[1] 武毅[4] 孙阳恩 齐晓丹 张学兰[1] ZHAO Xin;ZHANG Yanxu;LI Li;WU Peng;WU Yi;SUN Yang’en;QI Xiaodan;ZHANG Xuelan(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Dong’e Ejiao Co.Ltd.,Liaocheng 252201,China;National Engineering Research Center for Gelatin-Based Traditional Chinese Medicine,Liaocheng 252201,China;Nanjing Agricultural University,Nanjing 210095,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]东阿阿胶股份有限公司,山东聊城252201 [3]国家胶类中药工程研发中心,山东聊城252201 [4]南京农业大学,江苏南京210095

出　　处：《山东中医杂志》2020年第7期726-731,共6页Shandong Journal of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(编号:2018YFC1707204);国家自然科学基金项目(编号:81573606,81973486,31872514);山东省中医经典名方协同创新中心资助项目(编号:2018KFY03)。

摘　　要：目的:优选甘草饮片的炮制工艺。方法:以饮片外观性状、含水量、总灰分及甘草苷、甘草酸含量为评价指标,采用高效液相色谱(HPLC)法考察软化温度、闷润时间、润透时吸水量、干燥温度、干燥时间对甘草炮制质量的影响,优选适合生产实际的炮制工艺参数。结果:甘草最佳炮制工艺:取原药材,除去杂质,大小分档,洗净,软化温度5~25℃,小档闷润时间18~24 h,大档闷润时间48~72 h,至内外湿度一致,润透时吸水量为28%~38%,切厚片,60~70℃条件下干燥4~5 h。结论:优选的甘草软化和干燥工艺合理可行,适合大生产,为甘草饮片的规范化生产提供了技术支持。Objective:ObjectiveTo optimize the processing technology of Radix et Rhizoma Glycyrrhizae slices.Methods:The appearance and characteristics of Radix et Rhizoma Glycyrrhizae slices,moisture content,total ash and the contents of liquirtin and glycyrrhizic acid were used as the evaluation indexes,the effects of different processing parameters,such as steaming temperature,moistening time,water absorption during moistening,drying temperature and drying time,on the quality of Radix et Rhizoma Glycyrrhizae slices were investigated by high performance liquid chromatography(HPLC)method,so as to optimize processing parameters suitable for production practice.Results:The best processing technology of Radix et Rhizoma Glycyrrhizae was as follows:Remove impurities from crude drugs,separate into different categories according to the size,wash,soften at temperature of 5~25℃,at small scale moisten for 18~24 h,at large scale moisten for 48~72 h,when the internal and external humidity reaching the same,with water absorption at 28~38%,cut into thick slices,and dry for 4~5 h at 60~70℃.Conclusion:These optimized softening and drying process for Radix et Rhizoma Glycyrrhizae are reasonable and feasible,which could provide a technical support for the standard production of Radix et Rhizoma Glycyrrhizae slices.

关 键 词：甘草饮片 炮制工艺 甘草苷 甘草酸 高效液相色谱法 

分 类 号：R283.3[医药卫生—中药学]