痛风石形成相关危险因素研究进展  

Research progress on risk factors of tophus formation

作　　者：马利丹[1] 李鑫德[1] 辛颖[1] 贾兆通[1] Ma Lidan;Li Xinde;Xin Ying;Jia Zhaotong(Department of Endocrinology and Metabolic Diseases,the Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院内分泌与代谢性疾病科,266003

出　　处：《中华全科医师杂志》2020年第6期554-557,共4页Chinese Journal of General Practitioners

基　　金：国家自然科学基金(81801434)。

摘　　要：痛风石是慢性痛风的标志,痛风石的形成可导致骨质破坏、关节功能障碍等,增加患者心血管疾病和死亡风险。痛风石为慢性异物肉芽肿样结构,中性粒细胞胞外网状陷阱可能是痛风石形成的主要机制。多种因素可导致痛风石的形成。本文综述近年来对痛风石的生物学、相关危险因素及治疗等方面的研究进展。Tophus is the sign of chronic gout,which can lead to bone destruction,joint dysfunction,and significantly increase the risk of cardiovascular disease and death.Tophus has a structure of chronic foreign body granuloma,and extracellular reticular trap of neutrophils may be the main mechanism for the formation of tophi.Several factors can lead to the tophus formation.This article reviews the recent advances in the study of biology,risk factors and therapy of tophus.

关 键 词：痛风 痛风石 危险因素 

分 类 号：R589.7[医药卫生—内分泌]