2012-2019年佛山地区人群丙型肝炎病毒感染状况分析  

Analysis of hepatitis C virus infection in Foshan population from 2012 to 2019

作　　者：吕微风 黄桂旭 莫巧旋 卓雪芽[1] 廖倩筠 LYU Weifeng;HUANG Guixu;MO Qiaoxuan;ZHUO Xueya;LIAO Qianjun(Department of Laboratory Medicine,Foshan Hospital of Traditional Chinese Medicine,Foshan,Guangdong 528000,China)

机构地区：[1]佛山市中医院检验医学中心,广东佛山528000

出　　处：《现代医药卫生》2020年第13期1995-1997,共3页Journal of Modern Medicine & Health

摘　　要：目的回顾性分析该院住院患者和体检人群2012-2019年丙型肝炎病毒(HCV)的抗体、RNA及谷丙转氨酶的检测结果,对该地区HCV的感染状况进行分析。方法收集2012年1月至2019年7月该院住院患者和体检人群的血清标本,采用酶联免疫吸附试验(ELISA)进行HCV抗体检测,并同时对抗体阳性的标本进行RNA及谷丙转氨酶的检测,然后观察不同年份、年龄段、性别间HCV感染状况的差异。结果共收集血清标本316968份,其中HCV抗体阳性1241例,总体阳性率为0.392%,其中男性阳性952例,女性阳性289例;且男性HCV抗体阳性率(0.511%)明显高于女性(0.221%),差异有统计学意义(P<0.05);不同年份人群的HCV抗体阳性率无显著差异(P>0.05);但不同年龄段的HCV抗体阳性率比较,差异有统计学意义(P<0.05),其中0~<20岁组最低(0.020%),40~<60岁组阳性率最高(0.553%);男性HCV抗体及HCV-RNA抗体双阳性患者的初诊谷丙转氨酶检测值异常率(51.32%)明显高于女性(43.78%),差异有统计学意义(P<0.05)。结论该地区HCV感染存在明显的性别差异,且男性多于女性;41~<60岁是HCV感染的高发年龄段,医院应重点筛查;不同年份之间HCV阳性率无明显上升或下降趋势,因此,该地区HCV感染水平趋于稳定。Objective Retrospective analysis was made of the detection results of hepatitis C virus(HCV)antibody,RNA and alaine aminotransferase in hospitalized patients and physical examination population from 2012 to 2019,so as to understand the epidemic trend of the infections in Foshan area.Methods Serum samples from inpatients and checkups in our hospital from January 2012 to July 2019 were collected.The HCV antibody in serum samples was detected by enzyme-linked immunosorbent assay(ELISA),and the HCV antibody-positive samples were tested for RNA and alanine aminotransferase.After that,the differences in HCV infection between different years,different age groups and genders were observed and analyzed.Results A total of 316968 blood specimens were collected,of which 1241 were HCV antibody positive,the overall positive rate was 0.392%;there were 952 male cases and 289 female cases with positive HCV antibody,and the male HCV antibody-positive rate(0.511%)was higher than that of females(0.221%),the difference was statistically significant(P<0.05);the HCV antibody positive rates in different years were not significantly different(P>0.05).However,the positive rates of different age groups were significantly different,with the lowest in the 0-20 age group(0.020%)and the highest in the 40-<60 age group(0.553%).The abnormal rate of detection of alanine aminotransferase in male patients with HCV antibody and HCV-RNA double positive(51.32%)was higher than that of female(43.78%),the difference was statistically significant(P<0.05).Conclusions There is a significant gender difference in HCV infection in this region.There are more male HCV infections than females.The 40-<60 age group is a high-risk age group for HCV infection.There is no significant difference in HCV positive rate between different years,it indicates that the level of HCV infection in foshan region tends to be stable.

关 键 词：丙型肝炎病毒 性别 年龄 抗体 谷丙转氨酶 

分 类 号：R512.6[医药卫生—内科学] R392.7[医药卫生—临床医学]