磁共振成像纹理分析评价移植肾功能损伤的价值  

Value of magnetic resonance imaging texture analysis in evaluating renal allograft injury

作　　者：潘靓[1] 邢兆宇[2] 邢伟[1] 陈杰[1] 丁玖乐[1] 查婷婷[1] 张艳文[1] Pan Liang;Xing Zhaoyu;Xing Wei;Chen Jie;Ding Jiule;Zha Tingting;Zhang Yanwen(Department of Radiology,First People′s Hospital of Changzhou,Changzhou 213003,China;Department of Urology,First People′s Hospital of Changzhou,Changzhou 213003,China)

机构地区：[1]常州市第一人民医院放射科,常州213003 [2]常州市第一人民医院泌尿外科,常州213003

出　　处：《中华医学杂志》2020年第23期1768-1772,共5页National Medical Journal of China

基　　金：国家自然科学基金面上项目(81371513,81971572);常州市卫生局青年人才科技项目(QN201813);常州市科技计划(CJ20190084)。

摘　　要：目的探讨磁共振成像(MRI)纹理分析评价移植肾功能损伤的价值。方法回顾性分析2013年11月至2016年12月在常州市第一人民医院行异体肾移植术的66例患者资料[男42例,女24例,年龄22~63(40±10)岁]。根据患者MRI检查当日的估算肾小球滤过率(eGFR)分为移植肾功能良好(nRAF)组(15例)、移植肾功能轻中度损伤(mRAI)组(18例)、移植肾功能重度损伤(sRAI)组(33例)。所有患者术后1年内行常规T2加权像(T2WI)、磁敏感加权成像(SWI)、血氧水平依赖(BOLD)MRI扫描(一次检查完成所有MRI扫描),提取移植肾MRI纹理特征,分别筛选出与eGFR相关系数|r|≥0.3(P<0.05)且Boruta算法Z值最高的T2WI、SWI、BOLD纹理特征。采用受试者工作特征(ROC)曲线分析MRI纹理特征鉴别nRAF组、mRAI组、sRAI组的诊断效能。结果筛选出与eGFR相关系数|r|≥0.3(P<0.05)且Boruta算法Z值最高的MRI纹理特征为T2WI_Perc.50%、SWI_Perc.01%、BOLD_S(4,4)Contrast、BOLD_S(5,5)Correlat。T2WI_Perc.50%、SWI_Perc.01%、BOLD_S(5,5)Correlat鉴别nRAF组与mRAI组的ROC曲线下面积(AUC)分别为0.785、0.720、0.700。T2WI_Perc.50%、SWI_Perc.01%、BOLD_S(4,4)Contrast、BOLD_S(5,5)Correlat鉴别nRAF组与sRAI组的AUC分别为0.687、0.733、0.784、0.737。BOLD_S(4,4)Contrast鉴别mRAI组与sRAI组的AUC为0.667。结论MRI纹理分析能够为评估移植肾功能损伤提供有价值的信息。Objective To explore the value of magnetic resonance imaging(MRI)texture analysis in evaluating renal allograft injury.Methods A retrospective review was performed on sixty-six patients who underwent allograft renal transplantation(42 males,24 females;age range,22-63 years;mean age,(40±10)years)between November 2013 and December 2016.All the patients were divided into three groups according to their eGFR on the day of MRI examination:normal renal allograft function(nRAF)group(n=15),mild to moderate renal allograft injury(mRAI)group(n=18),and severe renal allograft injury(sRAI)group(n=33).All the patients underwent conventional T2 weighted image(T2WI),susceptibility weighted imaging(SWI),and blood-oxygen level dependent(BOLD)MRI examination.MRI texture features of renal allograft were extracted.The texture features based on T2WI,SWI,and BOLD with absolute correlation coefficient of eGFR greater than or equal to 0.3(P<0.05)and also with the highest Z value for Boruta algorithmwere selected.The diagnostic performance of the selected texture features in differentiating the three groups was assessed by receiver operating characteristic(ROC)curve analysis.Results T2WI_Perc.50%,SWI_Perc.01%,BOLD_S(4,4)Contrast,and BOLD_S(5,5)Correlat with absolute correlation coefficient of eGFR greater than or equal to 0.3(P<0.05)and also with the highest Z value for Boruta algorithm were selected.The AUC for T2WI_Perc.50%,SWI_Perc.01%,and BOLD_S(5,5)Correlat in differentiating the nRAF group with the mRAI group was 0.785,0.720,and 0.700.The AUC for T2WI_Perc.50%,SWI_Perc.01%,BOLD_S(4,4)Contrast,and BOLD_S(5,5)Correlat in differentiating the nRAF group with the sRAI group was 0.687,0.733,0.784,and 0.737.The AUC for BOLD_S(4,4)Contrast in differentiating the mRAI group with the sRAI group was 0.667.Conclusion MRI texture analysis can provide valuable information for evaluating renal allograft injury.

关 键 词：磁共振成像 肾移植 纹理分析 

分 类 号：R445.2[医药卫生—影像医学与核医学] R699.2[医药卫生—诊断学]