Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart F ailure Rats via Inhibiting P38 MA PK Pathway  

作　　者：Mao LIU Jie FENG Qian DU Jiao AI Zhan LV 

机构地区：[1]Department of Cardiology,Cardiovascular Research Center,Afiliated Hospital of North Sichuan Medical College,Nanchong 637000,China [2]Department of Clinical Medicine,North Sichuan Medical College,Nanchong 637000,China

出　　处：《Current Medical Science》2020年第2期307-312,共6页当代医学科学（英文）

基　　金：This study was supported by grants from Scientific Research Development Program of North Sichuan Medical College(No.CBY16-A-ZD10);Nanchong Government-University Strategic Cooperation Project in Science and Technology(No.18SXHZ0505).

摘　　要：Paconiflorin(Pae)is a monoterpenoid glycoside compound and has many biological activitics,such as immunosuppression,anti-inflammation and anti-cell proliferation.However,the effects and mechanisms of Pae on chronic heart failure(CHF)remain unclear.This study was conducted to assess the effects and mechanisms of Pae on myocardial fibrosis in isoprenaline(Iso)-induced CHF rats.Pae(20 mgkg)was intragastrically administrated to CHF rats for 6 weeks.Cardiac structure and function were assessed.The protein and mRNA levels of transforming growth factorβ1(TGF-β1)and p38 were detected.C ompared to Iso group,Pae could alleviate myocardial fbrosis and improve cardiac function in CHF rats.The levels of collagen volume fraction(13.75%+3.77%vs.30.97%+4.22%,P<0.001)and perivascular collagen volume area(14.32%+2.50%v8.28.31%+3.16%,P<0.001)were significantly reduced in Pae group as compared with those in Iso group.The expression of TGF-BI protein(0.30+0.07 vs.0.66+0.07,P<0.05)and mRNA(3.51+0.44 vs.7.58+0.58,P<0.05)decreased significantly in Pac group as compared with that in Iso group.The expression of p38 protein(0.36+0.12 vs.0.81+0.38,P<0.05)and mRNA(3.84+0.05 vs.4.40+0.17,P<0.05)also decreased markedly in Pae group as compared with that in Iso group.Pae could attenuate myocardial fibrosis and improve cardiac function in CHF rats by down-regulating the p38 MAPK signaling pathway.

关 键 词：chronic heart failure paconiflorin myocardial fibrosis P38 transforming growth factorβ1 

分 类 号：R54[医药卫生—心血管疾病]