限进介质-分子印迹聚合物在药物分析样品前处理中的应用  

Application of restricted access material-molecularly imprinted polymers in sample preparation of pharmaceutical analysis

作　　者：王晓飞[1] 宋三孔[1] 白银亮[1] 刘铭佩[1] 孙延庆[2] 孟敏[2] WANG Xiao-fei;SONG San-kong;BAI Yin-liang;LIU Ming-pei;SUN Yan-qing;MENG Min(Lanzhou University Second Hospital,Lanzhou 730030,China;Gansu Provincial Hospital,Lanzhou 730300,China)

机构地区：[1]兰州大学第二医院,兰州730030 [2]甘肃省人民医院,兰州700300

出　　处：《药物分析杂志》2020年第5期785-794,共10页Chinese Journal of Pharmaceutical Analysis

基　　金：兰州大学第二医院博士科研基金(Ynbskyjj2015-1-27);兰州市科技计划项目(2018-3-34)。

摘　　要：限进介质-分子印迹聚合物(RAM-MIPs)作为一种新型功能材料,由于其能同时实现生物大分子(蛋白、核酸、腐殖酸)的排阻和待测物的选择性富集,现已广泛地应用于药物分析样品前处理中。本文系统地介绍了限进介质-分子印迹聚合物合成、分类及其在药物分析的样品前处理应用中的装置,并通过介绍其在药物分析样品前处理的应用实例,对其应用范围及发展现状进行分析。Restricted access material-molecularly imprinted polymers(RAM-MIPs)as a new functional material,has been widely applied in the sample preparation of pharmaceutical analysis,because of its ability to exclude macromolecules(such as proteins,nucleic acid,and humic acid)and selectively retain the target analytes.In this article,the chemical synthesis,categories and devices of the application of RAM-MIPs in sample preparation of pharmaceutical analysis are introduced.By presenting its application sample preparation of pharmaceutical analysis,the range and recent development of RAM-MIPs are also reviewed.

关 键 词：限进介质 分子印迹聚合物 样品前处理 药物分析 

分 类 号：R917[医药卫生—药物分析学]