经支气管镜介入治疗气管支气管结核导致腔内阻塞的临床研究  

Clinical study of endovascular obstruction caused by tracheobronchial tuberculosis treated by bronchoscopy

作　　者：叶涛生[1] 张娇红[1] 张培泽[1] 曾旋 徐宇翔 李敏[1] YE Taosheng;ZHANG Jiaohong;ZHANG Peize;ZENG Xuan;XU Yuxiang;LI Min(Respiratory Endoscopy Room,Shenzhen Third People's Hospital,Guangdong Province,Shenzhen 518000,China)

机构地区：[1]广东省深圳市第三人民医院呼吸内镜诊疗室,广东深圳518000

出　　处：《中国医药导报》2020年第16期86-89,共4页China Medical Herald

基　　金：广东省医学科学技术研究基金项目(B2018045)。

摘　　要：目的 探讨经支气管镜介入治疗气管支气管结核导致腔内阻塞的临床研究.方法 选取2018年5月~2019年5月于广东省深圳市第三人民医院就诊的气管支气管结核导致腔内阻塞的患者380例,按照治疗方法 不同分为观察组与对照组,每组190例.对照组采用常规规范抗结核治疗,观察组在对照组治疗的基础上采用支气管镜介入治疗.比较两组痰菌转阴率、外周血炎性因子、呼吸困难程度、气管内径及肺功能,同时对两组经治疗后出现的并发症及治疗效果进行评价.结果 观察组痰转阴率明显高于对照组(P<0.05);与治疗前比较,治疗后两组肿瘤坏死因子-α、白细胞介素-6、C反应蛋白均降低,且观察组低于对照组(P<0.05);与治疗前比较,治疗后两组呼吸困难程度降低,且观察组低于对照组(P<0.05);与治疗前比较,两组气管内径与第1秒用力呼气容积升高,且观察组高于对照组(P<0.05);观察组并发症总发生率低于对照组,且治疗总有效率高于对照组(P<0.05).结论 支气管镜介入治疗管支气管结核导致腔内阻塞疗效可靠,安全性高,值得临床推广使用.Objective To investigate the clinical study of endovascular obstruction caused by tracheobronchial tuberculosis treated by bronchoscopy.Methods From May 2018 to May 2019,380 patients with endovascular obstruction caused by tracheobronchial tuberculosis in Shenzhen Third People′s Hospital were selected.According to different treatment methods,they were divided into the observation group and the control group,with 190 cases in each group.The control group was treated with routine standard anti-tuberculosis treatment,while the observation group was treated with bronchoscopy on the basis of the control group.The sputum negative conversion rate,peripheral blood inflammatory factors,dyspnea degree,inner diameter of trachea and pulmonary function were compared between the two groups.At the same time,the complications and therapeutic effect of the two groups were evaluated.Results The sputum negative conversion rate of the observation group was significantly higher than the control group(P<0.05).Compared with before treatment,the tumor necrosis factor-α,interleukin-6 and C-reactive protein decreased in the two groups after treatment,the observation group was lower than that in the control group(P<0.05).Compared with before treatment,the dyspnea degree decreased of the two groups,and the observation group was lower than that of the control group(P<0.05).Compared with before treatment,the inner diameter of trachea and the first second forced expiratory volume increased in the two groups,and the observation group was higher than those in the control group(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and the total effective rate of treatment was higher than that in the control group(P<0.05).Conclusion Endobronchial obstruction caused by tracheobronchial tuberculosis treated by bronchoscopy is reliable and safe,which is worthy of clinical application.

关 键 词：支气管镜 介入治疗 气管支气管结核 腔内阻塞 临床研究 

分 类 号：R47[医药卫生—护理学]