低分子肝素钙治疗急性加重期慢性阻塞性肺疾病的疗效分析  

Effect analysis of low molecular weight heparin calcium on acute exacerba tion of chronic obstructive pulmonary disease

作　　者：李志强[1] 杜艳君[1] 张丽 王宝霞 王秀伟 彭旭涛 Li Zhiqiang;DU Yanjun;Zhang Li;Wang Baoxia;Wang Xiuwei;Peng Xutao(Fangshan District First Hospital,Beijing 102400;Quyang Hospital of Traditional Chinese Medicine,Baoding,Hebei,Quyang 073199)

机构地区：[1]北京市房山区第一医院,北京102400 [2]河北省保定市曲阳县中医院,河北曲阳073199

出　　处：《当代医药论丛》2020年第10期7-10,共4页

基　　金：首都医学发展基金资助项目:1009-1006。

摘　　要：目的:探讨用低分子肝素钙治疗急性加重期慢性阻塞性肺疾病的临床疗效。方法:选取2016年1月至2019年1月期间北京市房山区第一医院收治的急性加重期慢性阻塞性肺疾病患者207例作为研究对象。将其随机分为抗凝组(n=106)和对照组(n=101)。在两组患者入院后,对其均进行常规治疗。在此基础上,为抗凝组患者应用低分子肝素钙进行治疗。然后对比两组患者的治疗效果和不良反应的发生情况。结果:1)治疗后,两组患者的FEV1/FVC、TLC、PaO2均较治疗前明显提高,其PaCO2均较治疗前明显降低,P<0.05。治疗后,抗凝组患者的FEV1/FVC、TLC、PaO2均高于对照组患者,其PaCO2低于对照组患者,P<0.05。2)治疗后,抗凝组患者血清FG、D-Dimer、HCY的水平均较治疗前明显降低,P<0.05;对照组患者血清FG、D-Dimer、HCY的水平与治疗前相比,P>0.05。治疗后,抗凝组患者血清FG、D-Dimer、HCY的水平均低于对照组患者,P<0.05。3)抗凝组患者治疗的显效率、治疗的总有效率均高于对照组患者,P<0.05。4)两组患者不良反应的发生率相比,P>0.05。结论:用低分子肝素钙对急性加重期慢性阻塞性肺疾病患者进行治疗的效果显著,可有效地改善其凝血指标及肺功能,且安全性较高。Objective:To investigate the clinical efficacy of low molecular weight heparin calcium in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods:207 patients with acute exacerbating chronic obstructive pulmonary disease admitted to The First Hospital of Fangshan District,Beijing from January 2016 to January 2019 were selected as study subjects.They were randomly divided into anticoagulant group(n=106)and control group(n=101).After admission,both groups received routine treatment.On this basis,low molecular weight heparin calcium was applied to the anticoagulant group.Then the treatment effect and the occurrence of adverse reactions were compared between the two groups.Results:1)After treatment,FEV1/FVC,TLC and PaO2 in both groups were significantly increased compared with that before treatment,and PaCO2 was significantly decreased compared with that before treatment,P<0.05.After treatment,FEV1/FVC,TLC and PaO2 in the anticoagulation group were all higher than those in the control group,and PaCO2 was lower than that in the control group(P<0.05).2)After treatment,serum FG,D-Dimer and HCY levels in the anticoagulant group were significantly lower than those before treatment(P<0.05).The serum levels of FG,d-dimer and HCY in the control group were 0.05 compared with those before treatment.After treatment,the serum levels of FG,D-Dimer and HCY in the anticoagulation group were all lower than those in the control group(P<0.05).3)The significant efficiency and total effective rate of treatment in the anticoagulation group were higher than those in the control group(P<0.05).4)the incidence of adverse reactions between the two groups was P>0.05.Conclusion:Low molecular weight heparin calcium is effective in the treatment of acute exacerbations of chronic obstructive pulmonary disease.It can effectively improve the coagulation index and lung function,and is safe.

关 键 词：低分子肝素钙 急性加重期慢性阻塞性肺疾病 临床疗效 

分 类 号：R563[医药卫生—呼吸系统]