高胆红素血症新生儿红细胞免疫功能状态及继发血小板增多症的临床研究  

Clinical study on erythrocyte immune function status and secondary thrombocytosis in hyperbilirubinemianeonates

作　　者：胡永艳 樊黎明 李慧娟 张涛 Hu Yongyan;Fan Liming;Li Huijuan;Zhang Tao(Department of Neonatology,the First People’s Hospital of Zhumadian,Zhumadian 463000,China)

机构地区：[1]河南省驻马店市第一人民医院新生儿科,463000

出　　处：《中国实用医刊》2020年第6期50-52,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨高胆红素血症新生儿红细胞免疫功能状态及继发血小板增多症情况。方法抽取2015年6月至2018年6月驻马店市第一人民医院收治的60例高胆红素血症新生儿作为观察组,其中血清胆红素浓度<200μmol/L 18例、200~300μmol/L 23例,>300μmol/L 19例,另选择本院产科的40例正常新生儿作为对照组,测定新生儿红细胞C3b受体花环率(RBC-C3bRR)和红细胞免疫复合物受体花环率(RBC-ICR),并记录继发性血小板增多症发生率和胆红素恢复正常时间。结果观察组RBC-C3bRR低于对照组,RBC-ICR高于对照组(P<0.05);观察组继发性血小板增多症的发生率高于对照组(P<0.05)。血清胆红素浓度>300μmol/L者RBC-ICR高于<200μmol/L、200~300μmol/L者,血清胆红素浓度200~300μmol/L者RBC-ICR高于血清胆红素浓度<200μmol/L者(P<0.05);不同浓度者RBC-C3bRR和继发性血小板增多症发生率比较差异未见统计学意义(P>0.05)。继发性血小板增多症患儿的血清胆红素浓度恢复正常时间短于血小板正常患儿(P<0.05)。结论高胆红素血症新生儿红细胞免疫功能低于正常新生儿,可导致血小板反应性增多,临床应引起重视,并给予积极治疗。Objective To investigate erythrocyte immune function(EIF)status and incidence of secondary thrombocytosis in hyperbilirubinemia(HB)neonates.Methods Sixty HB neonates who were admitted to the First People’s Hospital of Zhumadian from June 2015 to June 2018 were enrolled as observation group.Among them,18 patients of serum bilirubin level<200μmol/L,23 patients of serum bilirubin level 200-300μmol/L,and 19 patients of serum bilirubin level>300μmol/L.Another 40 normal neonatesin obstetric in our hospital were enrolled as control group.The red blood cell-C3b receptor rate(RBC-C3bRR)and red blood cell-immune complex rate(RBC-ICR)of the patients were measured.The incidence of secondary thrombocytosis and returning to normal time of bilirubin were recorded.Results RBC-C3bRR in observation group was lower than that in control group,while RBC-ICR was higher than that in control group(P<0.05).The incidence of secondary thrombocytosis in observation group was higher than that in control group(P<0.05).RBC-ICR was higher in patients with serum bilirubin concentration>300μmol/L than those in patients of<200μmol/L,200~300μmol/L,and those in patients of 200~300μmol/L were higher than R200-ICR(P<0.05).There was no significant difference in the incidence of RBC-C3bRR and secondary thrombocythemia in different concentrations(P>0.05).The returning to normal time of bilirubin concentration in neonates with secondary thrombocytosis was shorter than that in normal platelet patients(P<0.05).Conclusions EIF in HB neonates is lower than that in normal neonates,which can lead to reactive thrombocytosis.It should be paid attention to clinically and active treatment should be given.

关 键 词：高胆红素血症 新生儿 红细胞免疫功能状态 继发性血小板增多症 

分 类 号：R722[医药卫生—儿科]