Ag@Au core/shell triangular nanoplates with dual enzyme-like properties for the colorimetric sensing of glucose  

作　　者：Ao Liu Mengmeng Li Jingxiang Wang Fan Feng Yu Zhang Zhiwei Qiu Yuzhu Chen Benjamin Edem Meteku Congying Wen Zifeng Yan Jingbin Zeng 

机构地区：[1]College of Science,China University of Petroleum(East China),Qingdao 266580,China [2]Integrated Traditional Chinese and Western Medicine Hospital of Shandong,Qingdao 266002,China [3]State Key Laboratory of Heavy Oil Processing,China University of Petroleum(East China),Qingdao 266580,China [4]State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University,Changsha 410082,China

出　　处：《Chinese Chemical Letters》2020年第5期1133-1136,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.21876206);the Fundamental Research Funds for the Central Universities(No.18CX02037A)。

摘　　要：Due to the serious harm of diabetes to human health,development of sensitive assays for glucose level is of high significance for early prevention and treatment of diabetes.Currently,most conventional enzyme-based glucose sensors suffer from high cost and low stability due to the inherent defects of natural enzymes.Herein,we develop a pure nanozyme-based glucose detection method using Ag@Au core/shell triangular nanoplates(TNPs),which combines glucose oxidase(GOD)-and horseradish peroxidase(HRP)-like activities of the Au shell and inherent plasmonic properties of Ag TNPs.The sensing mechanism is based on the fact that the Au shell possessed GOD-like activity,enabling the oxidation of glucose to produce H2O2,which can further etch the silver core,leading to the decrease of absorbance at 800 nm and the color change from blue to colorless.Compared with the previous nanozymes-based glucose sensors,our method avoids the use of enzymes and organic chromogenic agent.Moreover,the stability of the Ag@Au core/shell TNPs is much better than that of Ag TNPs due to the protection by the coating of the Au shell.This method was successfully applied to the detection of urine samples from patients with diabetes,indicating its practical applicability for real sample analysis.

关 键 词：Nanozyme Ag@Au core/shell NANOPLATES Etching glucose Colorimetric sensing 

分 类 号：R587.1[医药卫生—内分泌]