Dracomolphesin A-E,five 3,4-seco-phenylpropanoids with Nrf2 inducing activity from Dracocephalum moldavica  

作　　者：Huaran Zhang Lintao Xu Xiaoqing Liu Jiangjiang Fan Xiaoning Wang Tao Shen Shuqi Wang Dongmei Ren 

机构地区：[1]Department of Natural Product Chemistry,Key Laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Shandong University,Ji'nan 250012,China [2]Department of Thoracic Surgery,Qilu Hospital of Shandong University,Ji'nan 250012,China

出　　处：《Chinese Chemical Letters》2020年第5期1259-1262,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81973202);the Key Research and Development Program of Shandong Province (No. 2018GSF118085)。

摘　　要：Dracomolphesin A-E(1-5),five 3,4-seco-phenylpropanoids featuring an aromatic ring opened framework,were isolated from the aerial parts of Dracocephalum moldavica.The structures with absolute configurations were determined by spectroscopic methods coupled with Mosher method.Notably,these compounds represented an example of aromatic ring cleavage products of phenylpropanoids.The possible biosynthetic pathway of these compounds was proposed.Compounds 1,2,4 and 5 were demonstrated to be Nrf2 pathway activators.

关 键 词：3 4-seco-phenylpropanoids Dracocephalum moldavica Nrf2 pathway Dioxygenase Antioxidant 

分 类 号：R284[医药卫生—中药学]