Palladium-catalyzed meta-C—H bond iodination of arenes with I2  

作　　者：Min Liu Ling-Jun Li Jun Zhang Hui Xu Hui-Xiong Dai 

机构地区：[1]Chinese Academy of Sciences Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Shanghai 201203,China [2]State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100191,China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]School of Pharmaceutical Science,Shanxi Medical University,Taiyuan 030001,China

出　　处：《Chinese Chemical Letters》2020年第5期1301-1304,共4页中国化学快报（英文版）

基　　金：Shanghai Institute of Materia Medica,Chinese Academy of Sciences,National Natural Science Foundation of China(No.21772211);Youth Innovation Promotion Association CAS(Nos.2014229 and 2018293);Institutes for Drug Discovery and Development,Chinese Academy of Sciences(No.CASIMM0120163006);Science and Technology Commission of Shanghai Municipality(No.17JC1405000);Program of Shanghai Academic Research Leader(No.19XD1424600);National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”,China(No.2018ZX09711002-006);the State Key Laboratory of Natural and Biomimetic Drugs for financial support。

摘　　要：Palladium-catalyzed highly meta-selective C—H iodination of phenylacetic acid,benzylphosphonate and benzylsulfonate scaffolds with molecular I2 is developed using a pyridine-type template.The practical ester linkages enable the directing template easily installed and readily removed.The substrate scope is broad,and alkyl,methoxyl,trifluomethyl,and halo substituents are compatible with this reaction.Further transformations of ibuprofen iodide intermediates by Pd-catalyzed C—C and C-heteroatom bond formation illustrate the broad utility of this method.

关 键 词：Palladium catalysis meta-C-H iodination Pyridine-based template Practical ester linkages Molecular I2 

分 类 号：O621.251[理学—有机化学]