Stereospecific access to bridged[n.2.1]skeletons through gold-catalyzed tandem reaction of indolyl homopropargyl amides  

作　　者：Tong-De Tan Xin-Qi Zhu Mei Jia Yongjia Lin Jun Cheng Yuanzhi Xia Long-Wu Ye 

机构地区：[1]iChEM,State Key Laboratory of Physical Chemistry of Solid Surfaces and Key Laboratory for Chemical Biology of Fujian Province,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China [2]College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou 325035,China [3]State Key Laboratory of Organometallic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Chemical Letters》2020年第5期1309-1312,共4页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China(Nos.21622204,21572186,21772161,21572163 and 21372178);the Natural Science Foundation of Fujian Province of China(No.2019J02001);the President Research Funds from Xiamen University(No.20720180036);NFFTBS(No.J1310024);PCSIRT;Science&Technology Cooperation Program of Xiamen(No.3502Z20183015)。

摘　　要：An efficient gold-catalyzed anti-Markovnikov cycloisomerization-initiated tandem reaction of Bocprotected indole tethered homopropargyl amides has been achieved.This method delivers a wide range of valuable bridged aza-[n.2.1]skeletons(n=3-7)at room temperature with high diastereoselectivity and enantioselectivity by a chirality-transfer strategy.Moreover,the gold-catalyzed tandem reaction of homopropargyl alcohol is also achieved to produce the bridged oxa-[3.2.1]skeleton.

关 键 词：GOLD HETEROCYCLES Cascade Homogeneous catalysis ALKYNES 

分 类 号：O621.251[理学—有机化学]