干扰素雾化吸入联合阿昔洛韦静脉滴注治疗传染性单核细胞增多症的疗效分析  

Efficacy analysis of interferon aerosol inhalation combined with acyclovir intravenous drip in the treatment of infectious mononucleosis

作　　者：张利 李劲松 高海英 ZHANG Li;LI Jing-song;GAO Hai-ying(Department of pediatrics,The People’s Hospital of Xili,Nanshan District,Shenzhen City,Guangdong Province,Shenzhen 518055,China)

机构地区：[1]广东省深圳市南山区西丽人民医院儿科,广东深圳518055

出　　处：《吉林医学》2020年第7期1550-1553,共4页Jilin Medical Journal

摘　　要：目的:研究干扰素雾化吸入联合阿昔洛韦静脉滴注治疗传染性单核细胞增多症(IM)的疗效。方法:选择收治的76例IM患儿实施研究,随机将其分为对照组和观察组,每组38例。其中对照组患儿进行阿昔洛韦静脉滴注治疗,观察组患儿则进行阿昔洛韦静脉滴注和干扰素雾化吸入治疗,比较两组患儿的治疗效果。结果:观察组患儿治疗显效率为52.63%,治疗有效率为97.37%,显著高于对照组的28.95%、78.95%,差异有统计学意义(χ^2=4.413、6.176,P=0.036、0.013);观察组患儿退热时间、颈部淋巴结肿大消退时间、肝脾肿大恢复时间以及咽峡炎好转时间均显著短于对照组,差异有统计学意义(t=2.838、7.653、15.338、7.586,P=0.006、0.000、0.000、0.000);观察组患儿免疫球蛋白G(Ig G)、免疫球蛋白M(Ig M)、免疫球蛋白A(Ig A)等免疫功能指标均显著高于对照组,EBV-DNA载量显著低于对照组,差异有统计学意义(t=46.630、7.858、9.866、19.768,P=0.000、0.000、0.000、0.000);两组患儿的不良反应相比,差异无统计学意义(χ^2=2.657,P=0.103)。结论:干扰素雾化吸入联合阿昔洛韦静脉滴注治疗IM患儿的效果更好,患儿各项体征消失较快,可有效调节患儿的免疫功能,不良反应少,可在临床上广泛推荐应用。Objective To study the efficacy of interferon aerosol inhalation combined with acyclovir intravenous drip in the treatment of infectious mononucleosis.Method 76 patients with infectious mononucleosis admitted to our hospital were selected as study subjects.They were randomly divided into control group and observation group with 38 cases in each group.The patients in the control group were treated with acyclovir intravenous drip.The patients in the observation group were treated with acyclovir and interferon aerosol inhalation.The therapeutic effects of the two groups were compared.Results The observation group with treatment efficiency was 52.63%,effective rate was 97.37%,significantly higher than that of control group were28.95%,78.95%(χ^2=4.413、6.176,P=0.036、0.013);Observation group with antifebrile time,neck lymph node enlargement fade,hepatosplenomegaly recovery time,and improved angina time were significantly shorter than the control group(t=2.838、7.653、15.338、7.586,P=0.006、0.000、0.000、0.000);Observation group with immunoglobulin G(Ig G),immunoglobulin M(Ig M),immunoglobulin A(Ig A)such as immune index were significantly higher than the control group,and EBVDNA loads was significantly lower than the control group(t=46.630、7.858、9.866、19.768,P=0.000、0.000、0.000、0.000);Compared two groups of children with adverse reaction,there was no statistically significant difference(χ^2=2.657,P=0.103).Conclusion The efficacy of interferon atomization inhalation combined with intravenous drip of acyclovir in the treatment of infectious monocytosis is better,and the signs of the patients disappear more quickly.Which can effectively regulate the immune function of patients,with less adverse reactions,which can be widely recommended for clinical use.

关 键 词：干扰素 雾化吸入 阿昔洛韦 静脉滴注治疗 传染性单核细胞增多症 

分 类 号：R725.1[医药卫生—儿科]