来曲唑对比克罗米芬治疗多囊卵巢综合征性不孕症的疗效  

The Efficacy of letrozole versus clomiphene citrate on the treatment of infertility caused by polycystic ovary syndrome

作　　者：邱昱 余晓完 QIU Yu;YU Xiao-wan(The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China)

机构地区：[1]福建医科大学附属第二医院,福建泉州362000

出　　处：《吉林医学》2020年第7期1735-1737,共3页Jilin Medical Journal

摘　　要：目的:对比来曲唑与克罗米芬治疗多囊卵巢综合征性不孕症的疗效差异。方法:选取96例多囊卵巢综合征性不孕症患者并随机分为对照组与观察组。对照组46例患者接受克罗米芬治疗,观察组50例患者接受来曲唑治疗。治疗周期结束后,对比两组患者妊娠成功率和不良反应的发生情况。结果:观察组成功妊娠率为60.00%,高于对照组的46.67%,差异有统计学意义(P<0.05)。观察组中不良反应发生的情况较少,但差异无显著统计学意义(P>0.05)。结论:来曲唑治疗多囊卵巢综合征性不孕症比克罗米芬的妊娠率高,同时不良反应发生较少,可以成为克罗米芬的替代药物。Objective To compare the efficacy of letrozole and clomiphene citrate in the treatment of infertility due to polycystic ovary syndrome.Method 96 patients with infertility due to polycystic ovary syndrome(PCOS)were selected and randomly divided into control group and observation group.In the control group,46 patients were treated with clomiphene citrate,and in the observation group 50 patients was treated with letrozole.After the end of the treatment cycle,the pregnancy success rate and the incidence of adverse reactions were compared between the two groups.Results The successful pregnancy rate in the observation group was 60.00%,which was higher than that in the control group(46.67%),and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was less,but there was no significant difference(P>0.05).Conclusion Letrozole has a higher pregnancy rate than clomiphene in the treatment of infertility due to polycystic ovary syndrome and has less adverse reactions,which can be used as a substitute for clomiphene.

关 键 词：不孕症 多囊卵巢综合征 来曲唑 克罗米芬 

分 类 号：R711.6[医药卫生—妇产科学] R711.75[医药卫生—临床医学]