大戟属植物二萜化学成分和药理活性研究新进展  

New Advance on the Research of Chemical Constituents and Pharmacological Activities of Diterpenoids from the Plants of Genus Euphorbia

作　　者：杨舜伊 袁纯红[2] 陈业高 Yang Shunyi;Yuan Chunhong;Chen Yegao(Key Laboratory of Plant Resources and Chemistry,Xinjiang Technical Institute of Physics and Chemistry,CAS,Urumqi 830011,China;Kunming Vocational and Technical College of Industry,Kunming 650302,China;Yunnan Normal University,Kunming 650092,China)

机构地区：[1]中国科学院新疆理化所植物资源化学重点实验室,新疆乌鲁木齐830011 [2]昆明工业职业技术学院,云南昆明650302 [3]云南师范大学,云南昆明650092

出　　处：《中国野生植物资源》2020年第6期53-60,共8页Chinese Wild Plant Resources

基　　金：云南省教育厅科学研究基金项目(2019J0301)。

摘　　要：目的:了解大戟属植物中二萜化学成分和药理活性的国内外研究最新状况。方法:查阅国内外有关大戟属植物研究的文献,了解上述两方面的基本情况。结果与讨论:2019年以来,国内外学者对大戟属植物进行大量研究,发现了97种新的二萜成分。药理研究表明,一些种及二萜成分在逆转P-糖蛋白介导的多药耐药性、细胞毒性、脂肪酶抑制活性、抗病毒和抗炎等方面具有显著的活性。开展大戟属植物二萜成分研究,对开发新的药用活性成分及资源利用具有重要意义。Objective:This study is to learned the chemical constituents and pharmacological activities of diterpenoids isolated in Euphorbia.Methods:Consulting the literature about the research of Euphorbia,to understand the basic situation of the above two aspects.Results and discussion:Since 2019,scholars have studied the genus Euphorbia and found 97 new diterpenoids.The study of pharmacological activities showed that some species and diterpenoids had significant activities in reversing P-glycoprotein-mediated multidrug resistance,cytotoxicity,lipase inhibition,antiviral and anti-inflammatory.It is of great significance to study the diterpenoid constituents of Euphorbia for the development of new pharmacological activities constituents and resource utilization.

关 键 词：大戟科 大戟属 二萜 药理活性 化学结构 

分 类 号：R282.6[医药卫生—中药学] R285.1[医药卫生—中医学]