Comments on ‘In vitro culture of cynomolgus monkey embryos beyond early gastrulation’  

作　　者：Huaixiao Ma Hongmei Wang Ping Zheng Lei Li 

机构地区：[1]State Key Laboratory of Genetic Resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China [2]State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [3]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China [4]Institute of Zoology,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Beijing 100049,China [5]Primate Research Center,Yunnan Key Laboratory of Animal Reproduction,Kunming Institute of Zoology,Kunming 650223,China [6]Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming 650223,China

出　　处：《Journal of Molecular Cell Biology》2020年第5期400-402,共3页分子细胞生物学报（英文版）

基　　金：National Key R&D Program of China(2018YFC1004500 ond 2017YFC1001401);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020700);‘light of West China’Program of Chinese Academy of Sciences.

摘　　要：The fertilized egg undergoes several cleavage divisions to form the blastocyst in the oviduct.The blastocyst then is transferred to the uterus to initiate implantation,and trophectoderm-derived cells interact with the maternal uterus.The dialogue between mother and embryo is prerequisite for the following embryonic development because a disturbance of this process mainly account for 60%pregnancy loss in human early post-implantation(Emiliani et al.,2005).After implantation,the embryo initiates the milestone event—gastrulation—during which multipotent epiblast cells(EPI)undergo an orchestrated process of morphogenetic cellular movement and differentiation.Through gastrulation,three germ layers(ectoderm,mesoderm,and endoderm)are specified to establish the body plan.Because the embryo is engulfed by maternal tissues and inaccessible,the direct observations and manipulations are obstructed.Currently,the knowledge on human early post-implantation development remains largely unknown.

关 键 词：IMPLANTATION CULTURE BEYOND 

分 类 号：Q95[生物学—动物学]