丁苯酞对缺血性脑卒中静脉溶栓后24 h内序贯治疗的有效性及安全性研究  

Efficacy and Safety of Butylphthalide in 24 h Sequential Therapy after Intravenous Thrombolysis for Ischemic Stroke

作　　者：李慧滢 孙博谦[1] 李威[1] 王玲玲[1] 李丹[2] LI Huiying;SUN Boqian;LI Wei;WANG Lingling;LI Dan(Affiliated Hospital of Beihua University,Jilin 132011,China;Jilin Provincial People’s Hospital,Changchun 130021,China)

机构地区：[1]北华大学附属医院,吉林吉林132011 [2]吉林省人民医院,吉林长春130021

出　　处：《北华大学学报（自然科学版）》2020年第3期358-361,共4页Journal of Beihua University（Natural Science）

基　　金：吉林省卫生与计划生育委员会项目(2018J084);北华大学研究生创新计划项目(2018022).

摘　　要：目的观察和评价丁苯酞注射液在超早期缺血性脑卒中静脉溶栓后24 h内序贯治疗的有效性和安全性.方法选取100例发病时间在4.5 h内的脑卒中患者,根据患者随机及自愿的原则,将其分为溶栓治疗组(常规治疗+rt-PA静脉溶栓)、丁苯酞序贯治疗组(常规治疗+rt-PA静脉溶栓+丁苯酞注射液序贯治疗),每组50例.两组患者常规基础治疗相同,丁苯酞注射液于溶栓后24 h内应用,剂量为100 m L,2次/d静点,时间间隔>6 h,连续治疗14 d,随访观察90 d,比较两组的疗效及安全性.结果溶栓后2周,溶栓治疗组和丁苯酞序贯治疗组患者的NIHSS评分分别为(6.28±2.69)分和(5.16±2.00)分,总有效率分别为80.0%和94.0%,差异具有统计学意义(P<0.05);治疗后随访90 d,溶栓治疗组和丁苯酞序贯治疗组患者的Bl评分分别为(79.20±8.41)分和(88.10±6.37)分,mRS评分分别为(1.94±0.93)分和(1.02±0.68)分,差异具有统计学意义(P<0.05).结论静脉溶栓后24 h内应用丁苯酞注射液可以显著改善患者的预后.Objective To observe and evaluate the efficacy and safety of butylphthalide injection in the sequential treatment of ultra-early ischemic stroke within 24 hours after intravenous thrombolysis.Method One hundred stroke patients who met the inclusion and exclusion criteria were selected as the study subjects,the onset time was within 4.5 hours.According to the principle of random and voluntary patients,they were divided into thrombolytic therapy group,namely routine treatment rt-PA intravenous thrombolytic therapy group,butyphthalide sequential therapy group,namely routine treatment rt-PA intravenous thrombolytic butyphthalide injection sequential therapy group,50 patients in each group.The patients in the two groups were treated with the same routine basic treatment.Butyphthalide injection was used within 24 hours after thrombolysis.The dose was 100 m L per day,2 times static point,over 6 hours interval,14 days continuous treatment,90 days follow-up observation,compared with the efficacy and safety of the two group.Results Two weeks after thrombolysis,the NIHSS scores of the thrombolytic therapy group and the butyphthalide sequential therapy group were(6.28±2.69)and(5.16±2.00),respectively,and the total effective rates were 80.0%and 94.0%,respectively.After 90 days of follow-up,patients in the control group had a BI score(79.20±8.41),while those in the treatment group had BI score(88.10±6.37),mRS,respectively(1.94±0.93)and(1.02±0.68),the difference was statistically significant(P<0.05).Conclusion Application of butylphthalide injection within 24 hours after intravenous thrombolysis can significantly improve the prognosis of patients.

关 键 词：静脉溶栓 丁苯酞注射液 序贯治疗 急性缺血性脑卒中 

分 类 号：R994.6[医药卫生—毒理学]