宫颈疾病与宫颈微生态特征的研究进展  

Progress in research on the correlation between cervical disease and characteristics of cervical microecosystem

作　　者：邓娟 王思雪 曹乐 方小玲[1] DENG Juan;WANG Sixue;CAO Le;FANG Xiaoling(Department of Gynaecology and Obstetrics,The Second Xiangya Hospital of Central South University,Changsha,Hu′nan 413000,China)

机构地区：[1]中南大学湘雅二医院妇产科,湖南长沙413000

出　　处：《中国微生态学杂志》2020年第5期606-609,共4页Chinese Journal of Microecology

摘　　要：宫颈微生态是一个复杂的生态系统,可随年龄、月经周期、妊娠、外源性因素等原因而发生动态变化,这种平衡对于机体健康至关重要。宫颈微生态包括菌群、局部pH、内分泌调节和免疫系统等,其中大量定植的宫颈菌群是微生态体系的核心组成部分。当发生感染、局部pH改变、雌激素减退等情况时,菌群生态平衡可被破坏,致病菌可过量繁殖成为优势菌,同时提升人乳头瘤病毒(HPV)感染风险,引起宫颈炎、宫颈鳞状上皮化生、宫颈癌等等。研究认为,宫颈微生态的改变与HPV感染、宫颈疾病的发生具有密切的相关性。然而国内关于宫颈微生态与宫颈疾病的直接关系的报道尚不多见,本文就宫颈微生态失衡与其引起的常见宫颈疾病,如宫颈炎、宫颈上皮内瘤变、宫颈癌等之间的相关性进行探讨。Cervical microecosystem is a complex ecosystem.Age,menstrual cycles,encyesis,external factors,etc.can cause dynamical changes of cervical microecosystem.The balance of cervical microecosystem is of significance to physical health.Cervical microecosystem includes bacteria,local pH,internal secretion and immune system,etc.,among them abundant colonial bacteria is the core of the microecosystem.As infections,local pH changes,estrogen reduction etc.occur,cervical microflora balance may be broken,pathogenic bacteria become the predominant bacteria after excess reproduction,and the risk of human papillomavirus(HPV)infection may increase at the same time,causing cervicitis,cervical squamous metaplasia and cervical carcinoma,etc..Some studies suggest that changes of cervical microecosystem are significantly associated with HPV infection and cervical diseases.However,the studies on direct relation between cervical microecosystem and cervical diseases are scarce.This study discusses the relation between unbalanced cervical microecosystem and common cervical diseases such as cervicitis,CIN and cervical carcinoma it caused.

关 键 词：宫颈微生态 宫颈炎 宫颈上皮内瘤变 宫颈癌 

分 类 号：R711.7[医药卫生—妇产科学]