产前超声检测对胎儿先天性异常诊断的符合率及其疾病影响因素分析  

Diagnostic accuracy of prenatal ultrasonography and influential factors in congenital anomalies of fetus

作　　者：卢薇薇[1] 郑吟诗[2] 刘丹青 魏小岳 李潜 Lu Weiwei;Zheng Yinshi;Liu Danqing;Wei Xiaoyue;Li Qian(Department of Ultrasonography,Shangqiu First People’s Hospital,Shangqiu,Henan 476100,China;Department of Imaging,Shangqiu First People’s Hospital,Shangqiu,Henan 476100,China)

机构地区：[1]商丘市第一人民医院超声科,河南商丘476100 [2]商丘市第一人民医院影像科,河南商丘476100

出　　处：《中华生物医学工程杂志》2019年第6期801-805,共5页Chinese Journal of Biomedical Engineering

摘　　要：目的探讨产前超声检测对胎儿先天性异常的疾病诊断符合率及其疾病影响因素。方法选取2016年12月至2018年12月商丘市第一人民医院确诊胎儿先天性异常的孕妇100例作为观察组,另选取同期200例胎儿正常的孕妇作为对照组,统计产前超声检测对胎儿先天性异常诊断符合率,并采用Logistic回归分析胎儿先天性异常危险因素。结果100例胎儿先天性异常经产前超声诊断85例,超声诊断符合率为85.00%(85/100);观察组和对照组各影响因素指标比较,差异均有统计学意义(均P<0.05);经Logistic回归分析孕期微生物感染、孕期发热、妊娠合并症、使用电脑、饲养宠物、居住地污染、丈夫吸烟、丈夫饮酒均为胎儿先天性异常的危险因素(OR1=5.127,OR2=2.531,OR3=3.135,OR4=1.988,OR5=2.004,OR6=6.103,OR7=2.012,OR8=2.196,均P<0.05),城镇居民、大专以上学历、孕前体育锻炼、补充叶酸则为胎儿先天性异常的保护因素(OR1=0.732,OR2=0.791,OR3=0.804,OR4=0.773,均P<0.05)。结论产前超声检测应用于胎儿先天性异常筛查具有高诊断符合率,胎儿先天性异常的影响因素较多,应及早采取预防与治疗措施,以避免不良妊娠结局。Objective To investigate the diagnostic accuracy of prenatal ultrasound detection and influencing factors in fetal congenital anomalies.Methods Included in this study were 100 pregnant women with congenital anomalies of the fetus confirmed in Shangqiu First People’s Hospital between December 2016 and December 2018,assigned as the study group.A contemporary cohort of 200 pregnant women with normal fetuses were enrolled as the control group.The accuracy of prenatal ultrasonography in detecting the fetal congenital anomalies was recorded.Logistic regression was used to analyze the influencing factors of fetal congenital anomalies.Results Among the 100 cases of congenital anomalies of the fetus,the diagnostic accuracy of prenatal ultrasonography was 85.00%(85/100).The two groups differed significantly in influencing factors(all P<0.05).Logistic regression analysis showed that microbial infections(OR1=5.127)and fever(OR2=2.531)during pregnancy,pregnancy comorbidities(OR3=3.135),computer use(OR4=1.988),pet raising(OR5=2.004),indoor pollution(OR6=6.103),smoking(OR7=2.012)and drinking(OR8=2.196)habits of the husband were risk factors,while urban residency(OR1=0.732),college education or higher(OR2=0.791),pre-pregnancy exercise(OR3=0.804),and folic acid supplementation(OR4=0.773)were protective factors of fetal congenital anomalies(all P<0.05).Conclusion Prenatal ultrasonography shows high diagnostic accuracy in fetal congenital anomalies.A number of influencing factors are involved in development of fetal congenital anomalies,rendering warranted early prevention and treatment measures against adverse pregnancy outcomes.

关 键 词：胎儿先天性异常 产前超声 诊断符合率 危险因素 保护因素 

分 类 号：R44[医药卫生—诊断学] R714[医药卫生—临床医学]